A control study of the mental health and cognitive function in the first-degree relatives of patients with high and sporadic incidence of obsessive-compulsive disorder
LIU Changcheng ZHANG Xinfeng XU Liming LU Xuemei▲
the Second Female Ward of Psychological Department, Jingzhou Mental Health Center, Hubei Province, Jingzhou 434000, China
Abstract：Objective To investigate the mental health status and the cognitive function in the first-degree relatives of patients with obsessive-compulsive disorder. Methods From June 2015 to June 2017, 72 first-degree relatives of patients with obsessive-compulsive disorder in Jingzhou Mental Health Center were selected as research objects and divided into the high incidence family group (48 cases) and the sporadic incidence family group (24 cases) according to the presence of others in the family. Hamilton anxiety scale (HAMA) and Yale-Brown obsessive compulsive scale (Y-BOCS) were used to assess the anxiety and compulsive symptoms. Stroop color word test (Stroop), Wisconsin card sorting test (WCST), continuous performance test (CPT) and brief visuospatial memory test-revised (BVMT-R) were applied to evaluate the cognitive function. Results ①The total scores of HAMA and Y-BOCS in the high incidence family group were all higher than those of sporadic family group, with statistically significant differences (2.6965, P ＜ 0.05). ②In the Stroop, the scores of B and C in the high incidence family group were lower than those of sporadic family group, with statistically significant differences (P ＜ 0.05). The WCST scale showed that the number of correctness and completed categories in the high incidence family group were lower than those of sporadic family group, with statistically significant differences (P ＜ 0.05), while significantly higher as regards the number of persistent error and random error (P ＜ 0.05). ③The score of CPT in the high incidence family group was significant lower than that of sporadic family group, with statistically significant difference (P ＜ 0.05).④BVMT-R showed that in terms of associative learning, group image free recall and memorizing the characteristics of human pictures in the high incidence family group were significant lower than those of sporadic family group, with statistically significant differences (P ＜ 0.05). Conclusion The first-degree family members of patients with high incidence of obsessive-compulsive disorder are more likely to show signs of anxiety and obsessive-compulsive symptom and more likely to suffer from cognitive impairment, such as attention and memory.
刘长成 张新风 徐黎明 陆雪梅▲. 强迫症患者高发与散发一级亲属心理健康状况及认知功能的对照研究[J]. 中国医药导报, 2018, 15(9): 163-166.
LIU Changcheng ZHANG Xinfeng XU Liming LU Xuemei▲. A control study of the mental health and cognitive function in the first-degree relatives of patients with high and sporadic incidence of obsessive-compulsive disorder. 中国医药导报, 2018, 15(9): 163-166.
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2018, Vol. 15 
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