1.Department of Obstetrics and Gynecology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China;
2.Medical Examination Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China;
3.Department of Clinical Medicine, Xiangya School of Medicine, Central South University, Hu′nan Province, Changsha 410013, China;
4.Department of Obstetrics and Gynecology, the First Hospital of Peking University, Beijing 100034, China
Abstract：Objective To study the relevant risk factors of metabolic disorders in pre- and post-menopausal women. Methods Eighty-four healthy women aged 45-55 years from 1st to 30th, June 2016 in Beijing Shijitan Hospital, Capital Medical University were chosen as the research object. According to the guidelines of the 2013 Chinese Diabetes Society (CDS) in metabolic syndrome (MS) diagnostic criteria, women were divided into normal metabolic group (n=39) and abnormal metabolic group (n=45). The general condition, reproductive history, past history, lifestyle and menopause symptoms were recorded through questionnaire and physical examination was done. Blood testing was performed, including anti Mullerian hormone (AMH), sex hormone, blood lipid, blood routine, blood biochemistry, etc. Univariate and multiple Logistic regression analysis were used for estimating odds ratios for the association of abnormal component factors in metabolic syndrome and the various factors. Results Univariate analysis showed that history of uterine leiomyoma, sitting time, frequencies of eating fruit, platelet count, platelet volume, platelet distribution width, uric acid, gamma glutamyl transferase and creatinine, the difference was statistically significant between group (P < 0.05). Multivariate Logistic regression showed that history of uterine leiomyoma (OR=9.219; 95%CI: 1.232-68.991; P=0.031) and increase of serum uric acid (OR=1.019; 95%CI: 1.003-1.035; P=0.019) were positively related to abnormal metabolic factors of metabolic syndrome. Conclusion Sedentary behavior, history of uterine leiomyoma and hyperuricemia may be the risk factors of metabolic abnormality in pre-and post-menopausal women. Fruit intake may have protective effect on metabolic syndrome. However, there was no correlation between ovarian function and metabolic syndrome.
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2018, Vol. 15 
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