Abstract：Objective To observe the effects of Dexmedetomidine on hemodynamics, emergence agitation and postoperative pain in children under anesthesia. Methods A total of 60 children with tonsillectomy and adenoidectomy in Renmin Hospital of Wuhan Universiy from March 2016 to March 2017 were selected and randomly divided into Dexmedetomidine group and control group, with 30 cases in each group. Children in the Dexmedetomidine group were given the Dexmedetomidine combined with Sevoflurane for maintenance of anesthesia, and children in the control group were given the Sevoflurane only for anesthesia maintenance. The operation time, anesthesia time, extubation time and recovery time, Heart rate (HR) and mean arterial pressure (MAP) were compared between the two groups in the times that before anesthesia (T0), tracheal intubation (T1), beginning of surgery (T2), end of surgery (T3). The incidence of emergence agitation, the PAED score and FPS score were investigated in the two groups. Results There were no statistically significant difference in operation time, anesthesia time, extubation time and recovery time between the two groups (P > 0.05). HR and MAP were higher at the time T1, T2 and T3 than those at T0 in both groups and there was no statistically significant difference in HR and MAP at T0 between the two groups (P > 0.05). Compared with the control group, HR and MAP at T1 and HR at T3 in the Dexmedetomidine group were lower than those in the control group, the differences were statistically significant (P < 0.05). The incidence of emergence agitation in the Dexmedetomidine group was lower than the control group, the PAED score and FPS score were lower in the Dexmedetomidine group than those in the control group, the differences were statistically significant (P < 0.05). Conclusion Dexmedetomidine can improve the hemodynamics, reduce emergence agitation and relieve postoperative pain in children, which increases the safety and comfort of anesthesia.
袁振武1,2 杨昌明2 王龙1▲. 右美托咪定用于小儿麻醉对血流动力学及对苏醒期躁动和术后疼痛的影响[J]. 中国医药导报, 2018, 15(7): 94-97,106.
YUAN Zhenwu1,2 YANG Mingchang2 WANG Long1▲. The Effects of Dexmedetomidine on hemodynamics, emergence agitation and postoperative pain in children. 中国医药导报, 2018, 15(7): 94-97,106.
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2018, Vol. 15 
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