生物膜仿生纳米颗粒在药物传递体系中的研究进展

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摘要生物膜涂层纳米技术是一种新兴的纳米载药仿生策略。该策略将具有不同特性的各种生物膜作为功能材料覆盖在载药纳米粒子表面，避免了传统化学手段修饰纳米颗粒的繁冗过程。得益于生物膜的伪装功能，这类仿生纳米载体获得原生物膜的天然属性，不仅本身的生物相容性得到解决，同时还具备体内长循环、病灶靶向等特点，目前已成功运用于药物呈递，在疾病精准诊断和治疗领域展示了广阔的应用前景。本文初步探讨了仿生纳米颗粒在药物传递体系中的研究进展，并对其未来研究进行展望。

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	田浩陈世春韩雨彤陈辅明马爱青鲁澄宇

关键词 ：生物膜, 仿生, 纳米颗粒, 药物传递

Abstract：Biomembrane-coated nanotechnology is a new biomimetic strategy for nanosystems. In this strategy, various kinds of biological membranes with versatile characteristics are used as functional materials and engineered on the surface of drug-loaded nano cores, which avoids the cumbersome process of traditional chemical methods to modify nanoparticles. Benefit from the camouflage function of biological membranes, the mimetic nanoparticles obtain the natural properties of the original biomembrane with good biocompatibility and characteristics of long circulation and lesion targeting. In the past few years, such biomimetic nanosystems have been successfully applied in drug delivery, showing broad application prospects in the fields of accurate diagnosis and treatment of diseases. This paper reviews the research progress of biomimetic nanoparticles in drug delivery system and prospect the future research.

Key words： Biomembrane Biomimetic Nanoparticles Drug delivery

基金资助:国家自然科学基金资助项目（21701033）；
广东医科大学科研基金项目（M2016006、B2017016）。

通讯作者: 马爱青（1978.7-），女，博士；研究方向：金属有机配合物及无机纳米材料的合成和生物活性研究。鲁澄宇（1967.3-），男，博士，教授；研究方向：骨药理学（药代动力学）研究。

作者简介: 田浩（1991.8-），男，广东医科大学研究生学院2015级药理学专业在读硕士研究生；研究方向：生物膜仿生纳米制剂抗肿瘤研究。

引用本文:

田浩陈世春韩雨彤陈辅明马爱青鲁澄宇. 生物膜仿生纳米颗粒在药物传递体系中的研究进展[J]. 中国医药导报, 2018, 15(7): 31-35.
TIAN Hao CHEN Shichun HAN Yutong CHEN Fuming MA Aiqing LU Chengyu. Research progress of biomembrane-biomimetic nanoparticles in drug delivery system. 中国医药导报, 2018, 15(7): 31-35.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2018/V15/I7/31

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