Abstract：Objactive To study the effects of Dexmedetomidine hydrochloride on hemodynamics and stress response in patients with pseudomyxoma peritonei. Methods Forty-six patients with pseudomyxoma peritonei in Beijing Aerospace Center Hospital from June 2015 to October 2017 were selected and devided into Dexmedetomidine group (24 cases) and control group (22 cases) by randomly number table method. After entered the operating room, patients of two groups were given the 0.5 μg/kg·h Dexmedetomidine or the same dose of normal saline, after 10 minutes, anesthesia induction. The blood samples were extracted and tested at the time before anesthesia induction (T1), 3 minutes after endotracheal intubation (T2), before intraperitoneal hyperthermic perfusion chemotherapy (T3), after thermal perfusion (T4), end of the surgery (T5). The heart rate (HR), MAP, cardiac output (CO), stroke volume variation (SVV), Tnose, blood glucose (Glu), plasma norepinephrine (NE) and epinephrine (E) were recorded. Results Hormone levels: the plasma E and NE levels in Dexmedetomidine group were lower than control group at T2-T5 (P ＜ 0.05). Hemodynamics: In Dexmedetomidine group of T3, T4 and T5, the change of CO and SVV was better than that of normal saline control group (P ＜ 0.05). The average MAP in Dexmedetomidine group was higher than the control group, the dosage of Propofol was lower than that of control group, the differences were statistically significant (P ＜ 0.05). There was no statistical significance between the two groups in preoperative, postoperative PCI index, CVP, Glu, time of operation, blood volume, urine volume and liquid amount (P ＞ 0.05). Conclusion Dexmedetomidine hydrochloride can reduce the reaction of injury in patients with pseudomyxoma peritonei, which is beneficial to reduce the hemodynamic fluctuation during the operation.
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2018, Vol. 15 
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