轻型复发性阿弗他溃疡患者铜锌血清含量的临床研究

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摘要目的比较轻型复发性阿弗他溃疡患者与健康人体内铜离子（Cu2+）和锌离子（Zn2+）的血清含量，探讨其与复发性阿弗他溃疡的关系。方法选取2015年3月～2016年12月在解放军白求恩国际和平医院（以下简称“我院”）口腔科确诊的97名轻型复发性阿弗他溃疡（MiRAU）患者和同期来我院体检的102名无MiRAU的健康人为研究对象。分别抽取溃疡发病期的患者（A组）和健康人（B组）5 mL空腹静脉血，再采用色度法检测受试者体内Cu2+和Zn2+的血清浓度。结果 A、B两组受试者体内Cu2+的血清浓度分别为（16.77±3.89）μmol/L和（17.62±3.05）μmol/L，组间差异无统计学意义（P ＞ 0.05）；A组受试者血清中的Zn2+浓度[（14.39±1.86）μmol/L]显著低于B组[（16.18±2.46）μmol/L]（P < 0.05）。结论锌离子血清含量的降低可能与复发性阿弗他溃疡存在着某种关联性。

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	张子川1 王鸿雁2 陈光1 吴仲寅1 方会清1

关键词 ：复发性阿弗他溃疡, 铜, 锌, 色度法

Abstract：Objective To compare the serum content of iron and Copper Zinc in patients with minor recurrent aphthous ulcer (MiRAU) and healthy individuals, and then to analyze that whether there is a possible relationship between them and recurrent aphthous ulcer. Methods Ninty-seven patients with minor recurrent aphthous ulcer (MiRAU) confirmed in Department of Stomatology of Bethune International Peace Hospital (hereinafter referred to as "our hospital") from March 2015 to December 2016 and 102 healthy persons without MiRAU in our hospital were enrolled. The patients with MiRAU (group A) and healthy persons (group B) were extracted 5 mL fasting venous blood respectively, and then the chromaticity method was used to detect the serum concentration of Copper and Zinc irons in subjects. Results The serum content of Copper iron in those subjects of group A and group B were (16.77±3.89) μmol/L and (17.62±3.05) μmol/L, and there was no significant difference between the two groups (P ＞ 0.05). The serum content of Zinc iron in those subjects of group A [(14.39±1.86)μmol/L] was significantly lower than that of group B [(16.18±2.46) μmol/L](P ＜ 0.05). Conclusion The decrease of serum content of Zinc iron may be associated with recurrent aphthous ulcer.

Key words： Recurrent aphthous ulcer Copper Zinc Colorimetric measurement method

基金资助:河北省卫生厅医学科学研究重点课题计划（ZL2014 0044）。

作者简介: 张子川（1982.10-），男，博士；研究方向：口腔黏膜病学的诊疗。

引用本文:

张子川1 王鸿雁2 陈光1 吴仲寅1 方会清1. 轻型复发性阿弗他溃疡患者铜锌血清含量的临床研究[J]. 中国医药导报, 2018, 15(6): 114-117.
ZHANG Zichuan1 WANG Hongyan2 CHEN Guang1 WU Zhongyin1 FANG Huiqing1. A clinical study of the serum content of copper iron and zinc iron in patients with minor recurrent aphthous ulcer. 中国医药导报, 2018, 15(6): 114-117.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2018/V15/I6/114

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