Meta analysis of the efficacy of San Jie Zhen Tong Capsules combined with Levonorgestrel Intrauterine System in treatment of adenomyosis
GU Zijuan1 LU Ruling2 YUAN Shuo2 DENG Gaopi2
1.Guangzhou University of Traditional Chinese Medicine, Guangdong Province, Guangzhou 510405, China;
2. Women and Children Center the second Department of Gynecology, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510405, China
Abstract:Objective To evaluate the clinical efficacy and safety of San Jie Zhen Tong Capsules combined with Levonorgestrel Intrauterine System in the treatment of adenomyosis. Methods Published papers about randomized controlled trials (RCTs) of San Jie Zhen Tong Capsules combined with Levonorgestrel Intrauterine System in the treatment of adenomyosis from the establishment of the database till December 10, 2017 with language restriction of Chinese and English were searched from various databases, which included PubMed, the Cochrane Library, Web of Science, CBM, Wanfang Data, CNKI, VIP. The subjects were divided into two groups, including Sanjie Zhentong capsules combined with Levonorgestrel Intrauterine System group and mere Levonorgestrel Intrauterine System group. Moreover, the observations including the total efficiency and the indexes of Lesion reduction rate and dysmenorrhea score and endometrial thickness and serum CA125 levels. In addition, a Meta-analysis was conducted with Review Manager 5.3 software. Results Six articles involving 602 patients were included. The Meta-analysis showed that there was a significantly positive effect of San Jie Zhen Tong Capsules combined with Levonorgestrel Intrauterine System in the treatment of adenomyosis. Conclusion San Jie Zhen Tong Capsules combined with Levonorgestrel Intrauterine System can improve not only the indexes of Lesion reduction rate (OR=17.94, 95%CI: [7.47, 43.10], P < 0.000 01), Dysmenorrhea score (MD=-1.72, 95%CI: [-3.37, -0.07], P=0.04), Endometrial thickness (MD =-1.52, 95%CI: [-1.77, -1.27], P < 0.000 01), Serum CA125 levels (MD =-5.74, 95%CI: [-8.12, -3.35], P < 0.000 01), but also the total efficiency (OR=5.38, 95%CI: [3.01, 9.63], P < 0.000 01) and it seems to have no obvious adverse reactions. Conclusion The evidences support that San Jie Zhen Tong Capsules combined with Levonorgestrel Intrauterine System have potential advantages compared to mere Levonorgestrel Intrauterine System therapy in the treatment of adenomyosis.
古子娟1 卢如玲2 袁烁2 邓高丕2. 散结镇痛胶囊联合曼月乐治疗子宫腺肌病的Meta分析[J]. 中国医药导报, 2018, 15(6): 88-93.
GU Zijuan1 LU Ruling2 YUAN Shuo2 DENG Gaopi2. Meta analysis of the efficacy of San Jie Zhen Tong Capsules combined with Levonorgestrel Intrauterine System in treatment of adenomyosis. 中国医药导报, 2018, 15(6): 88-93.