脓毒症急性肾损伤的研究机制及进展

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摘要急性肾损伤是严重脓毒症的最常见和严重的并发症之一。脓毒症急性肾损伤（SAKI）患者的发病率和死亡率居高不下。近年来，越来越多的研究表明线粒体动力学改变、自噬、氧化应激、炎性反应等机制在SAKI的形成过程中起到极其重要的作用。充分了解SAKI的发生发展机制，有助于更好地予以防治，有效降低发病率和病死率。因此，本文就SAKI的发生、发展机制作一综述。

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	郑婷杨定平▲

关键词 ：脓毒症, 急性肾损伤, 线粒体, 炎性反应, 氧化应激, 细胞凋亡, 自噬

Abstract：Acute kidney injury is one of the most common and serious complications of severe sepsis. And the incidence and mortality of patients with sepsis-induced acute kidney injury (SAKI) remained high. In recent years, more and more studies have shown that the mechanism of mitochondrial dynamics, autophagy, oxidative stress and inflammatory response plays an extremely important role in the formation of SAKI. Therefore, understanding the development mechanism of SAKI is helpful for better prevention and control, and effectively reduce morbidity and mortality. In this paper, the mechanism of occurrence and development of SAKI is reviewed.

Key words： Sepsis Acute kidney injury Mitochondrial；Inflammatory response Oxidative stress Apoptosis Autophagy

基金资助:国家自然基金资助项目（81670631）。

通讯作者: ▲通讯作者

引用本文:

郑婷杨定平▲. 脓毒症急性肾损伤的研究机制及进展[J]. 中国医药导报, 2018, 15(6): 24-27.
ZHENG Ting YANG Dingping▲ . Research progress and mechanism of sepsis-induced acute kidney injury. 中国医药导报, 2018, 15(6): 24-27.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2018/V15/I6/24

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