Curative effect of new nanocrystalline silver-zinc dressing on deep partial-thickness scald burn infection in rats
HUAN Ke1,2 BAI Bo1 BAI Xiaozhi3 SU Fei1 CHEN Xiao4 SANG Hongxun1,5
1.Department of Orthopaedics, Xijing Hospital of the Air Force Medical University, Shaanxi Province, Xi′an 710032, China;
2.Department of Orthopaedics, the Fourth People′s Hospital of Shaanxi, Shaanxi Province, Xi′an 710043, China;
3.Department of Burns and Cutaneous Surgery, Xijing Hospital of the Air Force Medical University, Shaanxi Province, Xi′an 710032, China;
4.Department of Laboratory Medicine, Xijing Hospital of the Air Force Medical University, Shaanxi Province, Xi′an 710032, China; 5.Department of Orthopaedics, Shenzhen Hospital of the South Medical University, Guangdong Province, Shenzhen
518101, China
Abstract：Objective To study the therapeutic effect of the new nanocrystalline silver-zinc dressing on deep partial-thickness scald burn infection. Methods 90 male SD rats were divided into three groups by random number table, with 30 rats in each group. Two deep partial-thickness scald wounds infected with Pseudomonas aeruginosa were established in the back of rats with consistent area and depth. Group A was treated with nano-silver dressing, group B was treated with nanocrystalline silver-zinc dressing, and group C was treated with ordinary sterile dressings when dressing change. The concentrations of interleukin -1 (IL-1), tumor necrosis factor alpha (TNF-α), interleukin -10 (IL-10) and transforming growth factor beta (TGF-β) in the tissues were detected by ELISA at 3, 6, 10 and 14 days after injury. Immunohistochemistry staining was used to observe the expression of inflammatory cytokines in group B, and the wound healing time of each group was recorded. Results At 3, 6, 10 and 14 days after injury, the levels of inflammatory factors IL-1 and TNF-α in group B were lower than those in group A and C, and the trend decreased with time prolonged, with statistically significant difference (P < 0.05). The concentration of IL-10 and TGF-β in group B was higher than those in group A and C, and the trend increased with time prolonged, with statistically significant difference (P < 0.05). Immunohistochemical staining was showed that the expression of inflammatory factor TNF-α in group B decreased with the prolongation of treatment time, and the expression of IL-10 increased gradually. The wound healing time of group B was shorter than those of group A and C, with statistically significant difference (P < 0.05). Conclusion The new nanocrystalline silver-zinc dressing has a better anti-infection and healing effect on deep partial-thickness scald burn infection.
郇科1，2 白博1 白晓智3 苏菲1 陈潇4 桑宏勋1，5. 新型纳米晶体银锌敷料对大鼠深Ⅱ度烫伤感染创面的疗效[J]. 中国医药导报, 2018, 15(6): 4-7.
HUAN Ke1,2 BAI Bo1 BAI Xiaozhi3 SU Fei1 CHEN Xiao4 SANG Hongxun1,5. Curative effect of new nanocrystalline silver-zinc dressing on deep partial-thickness scald burn infection in rats. 中国医药导报, 2018, 15(6): 4-7.
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2018, Vol. 15 
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