Significant of serum albumin, prealbumin, retinol binding protein and transferrin in postoperative parenteral nutrition support of gastric cancer
LIU Huilin1 ZHANG Dan2 DENG Xiangzhu3 LUN Limin2
1.Department of Clinical Laboratory Diagnostics Qingdao University Clinical Medical College, Shandong Province, Qingdao 266000, China;
2.Department of Clinical Laboratory, the Affiliated Hospital of Qingdao University, Shandong Province, Qingdao 266000, China;
3.Department of Clinical Laboratory, Qingdao Salt Worker′s Hospital, Shandong Province, Qingdao 266000, China
Abstract：Objective To study the nutritional monitoring value of serum albumin (ALB), prealbumin (PA), retinol binding protein (RBP), and transferrin (TRF) in parenteral nutrition support for patients after gastric cancer surgery. Methods From June 2016 to June 2017, 80 patients with gastric cancer surgery stayed in the Gastrointestinal Surgery, the Affiliated Hospital of Qingdao University were selected, and they were started with total parenteral nutrition (TPN) (≥5 d) on the first day after gastric cancer surgery. The serum specimen of blood routine examinations on the day of hospital admission (before surgery), on the first day and the sixth day after surgery were collected respectively, and changes of ALB, PA, RBP and TRF level in serum were measured respectively as well. Results ①Concentration changes of ALB, PA, RBP and TRF before surgery, on the first day after surgery and the sixth day after surgery were comparerd, the differences were statistically significant (P < 0.01). ②On the first day after surgery, ALB, PA, RBP and TRF dropped compared with before surgery, the differences were statistically significant (P < 0.01). ③On the sixth day after surgery, ALB, PA, RBP and TRF climbed up compared with the first day after surgery, the differences were statistically significant (P < 0.01). ④On the sixth day after surgery, PA and RBP were compared with before surgery, the differences were not statistically significant (P > 0.05), and ALB and TRF were compared with before surgery, the differences were statistically significant (P < 0.05). Conclusion Serum ALB, PA, RBP and TRF can reflect patients′ nutritional status and they play a guiding role in parenteral nutrition support for patients after gastric cancer surgery.
刘慧琳1 张丹2 邓祥竹3 伦立民2. 血清白蛋白、前白蛋白、视黄醇结合蛋白及转铁蛋白在胃癌术后肠外营养支持中的意义[J]. 中国医药导报, 2018, 15(5): 113-116.
LIU Huilin1 ZHANG Dan2 DENG Xiangzhu3 LUN Limin2. Significant of serum albumin, prealbumin, retinol binding protein and transferrin in postoperative parenteral nutrition support of gastric cancer. 中国医药导报, 2018, 15(5): 113-116.
[1] 刘同运，毛伟征，李杨，等.胃癌术后早期肠内营养支持的研究[J].中国现代普通外科进展杂志，2010，13（7）：868-870.
[2] 邹文斌，李兆申.中国胃癌发病率与死亡率研究进展[J].中国实用内科杂志，2014，34（4）：408-415.
[3] 刘洪一，王白石，张加金，等.早期肠内营养与肠外营养在胃癌根治术后应用效果比较[J].中国肿瘤临床，2014， 41（8）：1166-1169.
[4] Herranz Antolín S，Álvarez De Frutos V，Blasco Guerrero M，et al.Nutritional support with parenteral nutrition.Courseand associated complications [J]. Endocrinol Nutr，2013，60（6）：287-293.
[5] Soeters PB，Reijven PL，Schols JM，et al. A rational approach to nutritional assessment [J]. Clin Nutr，2008，27（5）：706-716.
[6] White JV，Guenter P，Jensen G，et al. Consensus statement of the academy of nutrition and dietetics/American society for parenteral andenteral Nutrition：characteristics recommended for the identification anddocumentation of adult malnutrition （undernutrition）[J]. J Acad Nutr Diet，2012， 112（5）：730-738.
[7] Wunderlich SM. Using plasma proteins for nutrition assessment [J]. J Am Diet Assoc，1989，89（9）：1236-1236.
[8] 尤久红，陈琦，蔡飞燕，等.规范化营养治疗在胃癌围手术期病人中的应用效果观察[J].肠外与肠内营养，2017， 24（1）：24-27.
[9] 王伟.早期肠内营养和肠外营养支持对早期胃癌切除术后患者的影响[J].中国肿瘤临床与康复，2015，22（6）：650-652.
[10] De Luis D，Lopez Guzman A. Nutritional status of adult patients admitted to internal medicine departments in public hospitals in Castillay Leon，Spain-A multi-center study [J]. Eur J Intern Med，2006，17（8）：556-560.
[11] 胡国强，陈威.含ω-3鱼油脂肪乳的肠外营养液对胃肠道肿瘤病人术后免疫与炎性因子的影响[J].肠外与肠内营养，2015，22（1）：16-19.
[12] 冯金华，黄明君，胡艳杰，等.加速康复外科对结直肠癌患者术后炎性指标和免疫功能影响的研究进展[J].重庆医学，2015，44（4）：548-551.
[13] 方玉，杨锐，辛晓伟，等.消化道恶性肿瘤病人营养支持现况调查[J].肠外与肠内营养，2014，21（1）：31-34.
[14] Carter J，Szabo R，Sim WW， et al. Fast track surgery：a clinical audit [J]. Aust N Z J obstet Gynaecol，2010，50（2）：159-163.
[15] Correia MI，Waitzberg DL. The impact of malnutrition on morbidity，mortality，length of hospital stay and costs evaluated through a multivariate model analysis [J]. Clin Nutr，2003，22（3）：235-239.
[16] 冯禄，张凯.肠内肠外营养在胃癌病人术后临床价值的分析[J].肠外与肠内营养，2014，21（6）：336-339.
[17] 常颖，张晴，范锐心，等.恶性肿瘤住院病人营养风险和营养支持与临床转归的研究[J].肠外与肠内营养，2016， 23（2）：71-77.
[18] Tapia MJ，Ocon J，Cabrejas-Gomez C，et al. Nutrition-related risk indexes and long-term mortality in noncritically ill inpatients who receive total parenteral nutrition （prospective multicenter study） [J]. Clin Nutr，2015，34（5）：962-967.
[19] 郑雪莲，李玉珍，朱刚.血清前白蛋白、转铁蛋白及视黄醇结合蛋白在危重病人应用肠外营养支持中的意义[J].海南医学，2009，20（5）：278-279.
[20] 陈焕伟，甄作均，潘文松.前白蛋白和视黄醇结合蛋白在肠外营养评估中的意义[J].肠外与肠内营养，2001，8（3）：149-150.
2018, Vol. 15 
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