Etiological analysis of pediatric acute respiratory infection in Tongzhou District of Beijing
WU Hongbo1 LIU Wei1 YANG Hongxiu1 ZHANG Shuqin2 LI Lihua1
1.Children′s Center, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China;
2.the Fourth Clinical Medical School, Peking University Health Science Center, Beijing 100035, China
Abstract：Objective To detect the common pathogens of acute respiratory tract infection (ARI) of children in Tongzhou District of Beijing, so as to provide clinical evidences for the prevention and treatment of children′s ARI. Methods Children with ARI were enrolled who hospitalized in the Children′s Center of Beijing Luhe Hospital, affiliated to Capital Medical University from September 1st, 2015 to Augest 31st, 2017. 2 mL of venous blood was collected, and 8 kinds of common respiratory pathogens IgM antibody were detected by indirect immunofluorescence, including RSV, ADV, INFA, INFB and PIVs. Then etiology tendency was analyzed. Results A total of 1319 children were enrolled and 962 positive samples were detected, accounting for 72.93%. Among them, MP positive detection was the most, accounting for 61.85%, followed by INFB, CPn, RSV, INFA, PIVs and ADV in turn. Among the positive samples, single pathogenic infection accounted for 58.63%, two pathogenic infection (double infection) accounted for 38.36% and three or more pathogenic infection (multiple infection) accounted for 3.01%. The most common pathogens combination of double infection was MP and INFB. Pathogens infection showed obvious seasonal changes. MP infection mainly concentrated in September to November. INFB infection increased from September, reached a peak in November and December, then decreased gradually, and reached a peak again in the following March (P < 0.05). The susceptible ages of different pathogens were significantly different (P < 0.05). The peak age of single pathogen infection (MP or INFB) was 3 years old, while the age of the highest positive rate of double infection (MP and INFB) was 11 months-3 years old. Positive detection rate of pathogens was similar in female and male (P > 0.05). Pneumonia was the main cause of hospitalization. Among them, double infection (MP and INFB) was the main cause, accounting for 25.83%, followed by MP infection and INFB infection, respectively accounted for 25.39% and 13.84%. Myocardial damage was the most common complication, accounting for 21.45%. Conclusion The main pathogens of respiratory tract infection in this region are MP and INFB. The main types of infection are single infection and double infection (MP+INFB). The number of cases increase from the fall, peak in winter and reach a small peak in the following spring again. The single infection mostly occurs in 3-6 years old and double infection mainly occurs in 11 months-3 years old.
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2018, Vol. 15 
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