Abstract：Objective To investigate the relationship between cognitive function and depression in elderly amnestic mild cognitive impairment (aMCI) patients. Methods From January 2016 to February 2017, 105 elderly patients with mild cognitive impairment in Xuanwu Hospital Capital Medical University were selected, except 36 patients were not meet the inclusion criteria, finally, 69 cases of aMCI patients were studied. According to the scores of hamilton depression scale (HAMD), The elderly aMCI patients who met the study criteria were divided into aMCI non depression group (n=39) and aMCI depression group (n=30). In the same period, 38 normal elderly were selected as control group (NC group). The cognitive functions of the three groups were evaluated by the montreal cognitive assessment (MoCA) and the auditory verbal learning test (AVLT), and the correlation between the HAMD scores and the cognitive function with MoCA and AVLT was analyzed. Results The visual space and executive ability, naming, attention, delayed recall and total score of MoCA in aMCI non depression group and aMCI depression group were lower than those of NC group (P < 0.05, P < 0.01). The visual space and executive ability, attention, delayed recall and total score of MoCA in aMCI depression group were lower than those of aMCI non depression group (P < 0.05), among them, the score of delayed recall was the most significant (P < 0.01). The immediate recall, short delayed recall, long delayed recall, long delayed recognition and total score of AVLT in aMCI non depression group and aMCI depression group were lower than those of NC group (P < 0.01). The immediate recall, short delayed recall, long delayed recall and total score of AVLT in aMCI depression group were lower than those of aMCI non depression group (P < 0.05). The attention and delayed recall were significantly negatively correlated with each dimension score of HAMD (P < 0.05, P < 0.01), the visual space and executive ability, and the total score of MoCA were negatively correlated with each dimension scores (except weight) of HAMD (P < 0.05, P < 0.01). The anxiety/somatization, block and sleep disturbance were negatively correlated with each dimension score of MoCA and total score (P < 0.05, P < 0.01). The immediate recall, short delayed recall, long delayed recall and total score of AVLT were negatively correlated with each dimension scores of HAMD (P < 0.05, P < 0.01). The anxiety/somatization, block and sleep disturbance were negatively correlated with each dimension score of AVLT and total score (P < 0.05, P < 0.01). Conclusion The visual space and executive ability, attention, immediate recall and delayed recall of cognitive function in elderly aMCI patients with depressive disorder are lower than aMCI non depressive patients. Attention and delayed recall are significantly negatively correlated with anxiety, somatization, block and sleep disturbance in cognitive function of elderly aMCI patients.
刘妍 黄小波 陈文强 王宁群 陈玉静. 老年遗忘型轻度认知障碍患者认知功能与抑郁障碍的相关性分析[J]. 中国医药导报, 2018, 15(5): 66-70.
LIU Yan HUANG Xiaobo CHEN Wenqiang WANG Ningqun CHEN Yujing. Relationship of cognitive function and depression in elderly patients with amnestic mild cognitive impairment. 中国医药导报, 2018, 15(5): 66-70.
[1] Petersen RC，Smith GE，Waring SC，et al. Mild cognitive impairment：clinical characterization and outcome [J]. Arch Neurol，1999，56（3）：303-308.
[2] 中国防治认知功能障碍专家共识专家组.中国防治认知功能障碍专家共识[J].中华内科杂志，2006，45（2）：171-173.
[3] Petersen RC. Mild cognitive impairment as a diagnostic entity [J]. J Intern Med，2004，256（3）：183-194.
[4] Morris JC，Cummings J. Mild cognitive impairment（MCI）represents early-stage Alzheimer′s disease [J]. J Alzheimers Dis，2005，7（3）：235-239.
[5] Sperling RA，Aisen PS，Beckett LA，et al. Toward defining the preclinical stages of Alzheimer′s disease：recommendations from the National Institute On Aging-Alzheimer′s Association workgroups on diagnostic guidelines for Alzheimer’s disease [J]. Alzheimers Dement，2011，7（3）：280-292.
[6] 吕扬，李峥.轻度认知功能障碍与抑郁关系[J].中国老年学杂志，2015，35（11）：3164-3167.
[7] Dranovsky A，Hen R. Hippocampal neurogenesis：regulation by stress and antidepressants [J]. Biol Psychiatry，2006， 59（12）：1136-1143.
[8] 许贤豪，彭丹涛.神经心理量表检测指南[M].北京：中国协和医科大学出版社，2007.
[9] Portet F，Ousset PJ，Visser PJ，et al. Mild cognitive impairment（MCI）in medical practice：a critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer′s Disease [J]. J Neurol Neurosurg Psychiatry，2006，77（6）：714-718.
[10] 田金洲，时晶，张新卿，等.轻度认知损害临床研究指导原则（草案）[J].中西医结合学报，2008，6（1）：9-14.
[11] Nasreddine ZS，Phillips NA，Bédirian V，et al. The Montreal Cognitive Assessment，MoCA：a brief screening tool for mild cognitive impairment [J]. J Am Geriatr Soc，2005， 53（4）：695-699.
[12] Vuylsteke A，Sharples L，Charman G，et al. Circulatory arrest versus cerebral perfusion during pulmonary endarterectomy surgery（PEACOG）：a randomised controlled trial [J]. Lancet，2011，378（9800）：1379-1387.
[13] Wadsworth LP，Lorius N，Donovan NJ，et al. Neuropsychiatric symptoms and global functional impairment along the Alzheimer's continuum [J]. Dement Geriatr Cogn Disord，2012，34（2）：96-111.
[14] 关绍晨，汤哲，吴晓光，等.北京老年人群轻度认知障碍患病情况及危险因素的抽样调查[J].中国脑血管病杂志，2008，5（9）：395-398.
[15] Cooper C，Sommerlad A，Lyketsos CG，et al. Modifiable predictors of dementia in mild cognitive impairment：a systematic review and meta-analysis [J]. Am J Psychiatry，2015，172（4）：323-334.
[16] Ismail Z，Elbayoumi H，Fischer CE，et al. Prevalence of depression in patients with mild cognitive impairment：a systematic review and meta-analysis [J]. JAMA Psychiatry，2017，74（1）：58-67.
[17] Wilson RS，Aggarwal NT，Barnes LL，et al. Biracial population study of mortality in mild cognitive impairment and Alzheimer disease [J]. Arch Neurol，2009，66（6）：767-772.
[18] Shahnawaz Z，Reppermund S，Brodaty H，et al. Prevalence and characteristics of depression in mild cognitive impairment：the Sydney memory and ageing study [J]. Acta Psychiatr Scand，2013，127（5）：394-402.
[19] Gabryelewicz T，Styczynska M，Pfeffer A，et al. Prevalence of major and minor depression in elderly persons with mild cognitive impairment--MADRS factor analysis [J]. Int J Geriatr Psychiatry，2004，19（12）：1168-1172.
[20] Modrego PJ，Ferrández J. Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type：a prospective cohort study [J]. Arch Neurol，2004，61（8）：1290-1293.
[21] Johnson LA，Mauer C，Jahn D，et al. Cognitive differences among depressed and non-depressed MCI participants：a project FRONTIER study [J]. Int J Geriatr Psychiatry，2013，28（4）：377-382.
[22] Royall DR，Palmer RF. Alzheimer's disease pathology does not mediate the association between depressive symptoms and subsequent cognitive decline [J]. Alzheimers Dement，2013，9（3）：318-325.
[23] Hermida AP，McDonald WM，Steenland K，et al. The association between late-life depression，mild cognitive impairment and dementia：is inflammation the missing link [J]. Expert Rev Neurother，2012，12（11）：1339-1350.
[24] Byers AL，Yaffe K. Depression and dementias among military veterans [J]. Alzheimers Dement，2014，10（3 Suppl）：S166-S173.
[25] 魏小利，王锁良.益智活动对退休后老年人认知功能的影响[J].中国医药导报，2017，14（18）：177-180.
[26] 齐雪丹，许凡宇，范炤，等.轻度认知障碍及阿尔茨海默病的sMRI分析[J].中国当代医药，2017，24（8）：9-13.
[27] Orgeta V，Qazi A，Spector A，et al. Psychological treatments for depression and anxiety in dementia and mild cognitive impairment：systematic review and meta-analysis [J]. Br J Psychiatry，2015，207（4）：293-298.
2018, Vol. 15 
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