阻塞性睡眠呼吸暂停综合征患者血清同型半胱氨酸、胱抑素C表达水平及临床价值

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摘要目的探讨阻塞性睡眠呼吸暂停综合征（OSAHS）患者血清同型半胱氨酸、胱抑素C表达水平及其临床意义。方法选择2015年1月～2017年7月在山东省临朐县人民医院（以下简称“我院”）就诊的174例OSAHS患者作为OSAHS组，同时选取我院健康体检者90例作为对照组。比较两组血清同型半胱氨酸、胱抑素C水平，采用Pearson相关分析对同型半胱氨酸、胱抑素C与呼吸暂停低通气指数（AHI）进行相关分析。根据病情轻重将OSAHS患者分为轻、中、重三组，比较三组同型半胱氨酸、胱抑素C水平。结果 OSAHS组血清同型半胱氨酸、胱抑素C均高于对照组，差异有高度统计学意义（P ＜ 0.01）。Pearson相关性分析显示，血清同型半胱氨,、胱抑素C与AHI呈高度正相关（r = 0.79、0.74，P ＜ 0.01）。轻、中、重度OSAHS组同型半胱氨酸、胱抑素C比较，差异有统计学意义（P ＜ 0.05）。进一步两两比较，中、重度OSAHS组高于轻度OSAHS组，重度OSAHS组高于中度OSAHS组，差异均有统计学意义（P ＜ 0.05）。结论 OSAHS患者血清同型半胱氨酸、胱抑素C表达水平高于正常人群，并与患者AHI呈正相关，可作为辅助诊断及评估OSAHS病情的敏感指标。

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	王善全1 刘成洲1 刘同祥2

关键词 ：阻塞性睡眠呼吸暂停综合征, 同型半胱氨酸, 胱抑素C, 相关性分析

Abstract：Objective To explore the expression level of homocysteine and cystatin C in patients with obstructive sleep apnea syndrome and its clinical value. Methods From January 2015 to July 2017, 174 patients with OSAHS in People′s Hospital of Linqu County were selected as the OSAHS group. At the same time, 90 healthy people in the same hospital were selected as the control group. The levels of serum homocysteine and cystatin C in the two groups were compared. Pearson correlation analysis was used to analyze the correlation of homocysteine, cystatin C and apnea hypopnea index (AHI). Patients in OSAHS group were divided into mild, moderate and severe OSAHS group according to the severity of the disease and the homocysteine, Cystatin C in the three groups were compared. Results The homocysteine and cystatin C in the OSAHS group were higher than those of control group, with highly statistically significant differences (P ＜ 0.01). Pearson correlation analysis showed that serum homocysteine and cystatin C were positively correlated with AHI, with highly statistically significant differences (r = 0.79,0.74,P ＜ 0.01). There were statistically significant differences in homocysteine and cystatin C among the three OSAHS groups (P ＜ 0.05), the above indicators in moderate and severe OSAHS group were higher than those of mild OSAHS group and those in the severe OSAHS group were higher than those of moderate OSAHS group, with statistically significant differences (P ＜ 0.05). Conclusions The level of serum homocysteine and cystatin C in patients with OSAHS were significantly higher than those of normal population and are positively correlated with AHI, which can be used as a sensitive indicator for the diagnosis and evaluation of OSAHS.

Key words： Obstructive sleep apnea syndrome Homocysteine cystatin C Correlation analysis

通讯作者: 刘同祥（1963.1-），男，主任医师，教授，硕士研究生导师，山东省潍坊市人民医院急诊部主任；研究方向：呼吸及心血管疾病的基础与临床研究。

作者简介: 王善全（1975.10-），男，硕士，研究方向：呼吸系统疾病的临床研究。

引用本文:

王善全1 刘成洲1 刘同祥2. 阻塞性睡眠呼吸暂停综合征患者血清同型半胱氨酸、胱抑素C表达水平及临床价值[J]. 中国医药导报, 2018, 15(4): 73-76.
WANG Shanquan1 LIU Chengzhou1 LIU Tongxiang2. Levels and clinical value of serum homocysteine and cystatin C in patients with obstructive sleep apnea syndrome. 中国医药导报, 2018, 15(4): 73-76.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2018/V15/I4/73

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