Comparison of short-term efficacy between Albumin-Bound Paclitaxel and Docetaxel combined with Cisplatin in the treatment of locally middle and advanced nasopharyngeal carcinoma
LIU Guoying1 XIA Weixiong1 ZHANG Guangshun2 LYU Xing1 LI Wangzhong1 LIANG Hu1 GUO Xiang1 XIANG Yanqun1▲
1.Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangdong Province, Guangzhou 510060, China;
2.Department of Medical Physicists’ Room, Sun Yat-sen University Cancer Center, Guangdong Province, Guangzhou 510060, China
Abstract：Objective To compare the short-term efficacy of Albumin-Bound Paclitaxel combined with Cisplatin (AC) and Docetaxel combined with Cisplatin (DC) in the treatment of locally middle and advanced nasopharyngeal carcinoma. Methods From January 2016 to December 2019, the clinical data of stage Ⅲ-Ⅳa nasopharyngeal carcinoma patients who received AC or DC as induction chemotherapy from Sun Yat-sen University Cancer Center were collected retrospectively. After propensity score matching, there were 54 cases in each group. The short-term efficacy after induction chemotherapy and 3 months after completion of radio-chemotherapy were compared between the two groups, the disease progression and the incidence of adverse reaction in the two groups was observed. Results After induction chemotherapy and 3 months after completion of radio-chemotherapy, there were no significant differences in the total effective rate between two groups (P > 0.05). There was no significant difference in disease progression rate between the two groups (P ＞ 0.05). There was no significant differences in the toxicity and side effects of leukopenia, neutropenia, anemia and thrombocytopenia between the two groups (P > 0.05). Conclusion AC is well tolerated and effective in middle and advanced nasopharyngeal carcinoma, and the comparison of efficacy with DC still needs longer follow-up to be further confirmed.
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2021, Vol. 18 
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