Abstract：Objective To analysis the levels and differences of chitinase protein-40 (YKL-40) in serum and urine of patients with renal tuberculosis and renal tumors. Methods From May 2016 to May 2019, 100 patients with renal tuberculosis admitted to the First Affiliated Hospital of Hebei North University (hereinafter referred to as “our hospital”) were selected as renal tuberculosis group and 50 patients with renal tumor as renal tumor group. Meanwhile, 100 examinees who came to our hospital for physical examination at the same time were selected as the reference group, and YKL-40 levels in serum and urine of three groups of patients were detected by enzyme-linked immunosorbent assay. At the same time, the normal tissues around the lesion were collected and made into paraffin samples. The expression of YKL-40 in the lesion was observed by immunohistochemistry. The clinical data of all study samples were retrospectively analyzed. Compared the difference of YKL-40 levels in urine and serum between patients with renal tuberculosis and renal tumor and normal persons, and observed the expression of YKL-40 in pathological tissues and surrounding normal tissues of patients with renal tuberculosis and renal tumor. Results The level of YKL-40 in serum and urine samples of reference group was lower than that of renal tuberculosis group and renal tumor group (P ＜ 0.05). There was no significant difference in serum and urine YKL-40 levels between renal tuberculosis group and renal tumor group (P ＞ 0.05). The level of YKL-40 in pathological tissues of patients with renal tuberculosis and renal tumor was significantly higher than that in surrounding normal tissues (P ＜ 0.05). Conclusion The level of YKL-40 in urine and serum of patients with renal tuberculosis and renal tumor is significantly increased, which can be used as the basis for the preliminary diagnosis of the disease. However, in order to improve the diagnostic accuracy, it should be combined with other laboratory diagnostic criteria.
李秀君 安海霞 杨家鑫 陈怀安. 甲壳质酶蛋白-40在肾结核和肾肿瘤患者中的表达差异及临床意义[J]. 中国医药导报, 2021, 18(6): 95-98.
LI Xiujun AN Haixia YANG Jiaxin CHEN Huai’an. Expression difference and clinical significance of chitinase protein-40 in patients with renal tuberculosis and renal tumor. 中国医药导报, 2021, 18(6): 95-98.
2021, Vol. 18 
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