Abstract：Objective To explore the clinical application rules of softening handness and dispersing mass in treating vocal nodules and to explore the core drug combinations. Methods CNKI, Wanfang, VIP, CBM published literatures of Chinese herbal compound in the treatment of vocal nodules were searched by using computer. The key words were “ruanjian”, “sanjie”, “xiaojian” and “vocal nodule”, etc. The retrieval time was from the establishment of the database to September 2019. The data from the literatures to WPS 2019 was extracted and database for frequency statistical analysis was established. Clementine 12 was used to establish Apriori association analysis model. R-type clustering was conducted to further study the prescriptions of Chinese medicine by using SPSS 23.0. The core drug pairs and core prescriptions for vocal nodules were analyzed. Medication rules were explored. Results A total of 55 prescriptions of Chinese medicine were included, involving 133 kinds of Chinese medicine, and the frequency of use was 631. The first three rules supported by association rule analysis were: the first three rules with high support degree in association rule analysis were as follows: Semen Oroxyli → Radix Platycodonis, Sargassum → Thallus Laminariae, Rhizoma Curcumae → Rhizoma Sparganii, as the core drug pairs for the treatment of vocal nodules. Three core prescriptions were obtained by cluster analysis, Formula C1: Rhizoma Sparganii, Rhizoma Curcumae, Sargassum, Thallus Laminariae, Semen Persicae, Flos Carthami. Formula C2: Radix Scrophulariae, Radix Ophiopogonis, Radix Rehmanniae Recens, Bulbus Fritillariae Thunbergii, Spica Prunellae. Formula C3: Rhizoma Atractylodis Macrocephalae, Poria, Radix Platycodonis, Semen Oroxyli, Radix Glycyrrhizae. The prescriptions for the treatment of vocal nodules is mainly phlegm-resolving formula and blood-activating formula. Combined with syndrome differentiations, drugs of dispelling pathogenic wind, nourishing yin, nourishing blood, clearing heat and others were used. Conclusion The basic principle of treating vocal nodules is dissipating phlegm and resolving masses, resolving stasis and softening hardness. The medication mainly use the drugs of dissipating phlegm and resolving stasis, clearing heat and resolving masses, combine with strengthening vital qi.
刘彩凤 李思婷 王志国. 基于数据挖掘探讨软坚散结法治疗声带小结的用药规律[J]. 中国医药导报, 2021, 18(4): 119-122.
LIU Caifeng LI Siting WANG Zhiguo. Discussion on the medication rules of softening handness and dispersing mass in the treatment of vocal nodules based on data mining. 中国医药导报, 2021, 18(4): 119-122.
2021, Vol. 18 
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