Research progress on the function of lysine-specific demethylase 1
QIN Xuke1 WU Yingguang2 ZHONG Guangqing2 GUO Ji2 WANG Lei1 DU Yang1 CHEN Zhiyuan1 LIU Xiuheng1
1.Department of Urology, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430060, China;
2.the First Department of Surgery, Hai’nan Changjiang Medical Group, Hai’nan Province, Changjiang 572700, China
Abstract：Histone lysine-specific demethylase 1 （LSD1） can catalyze the demethylation of mono-or di-methyl-lysine 4 or 9 of histone H3 for regulating gene expression. Through its demethylation function, LSD1 is involved in a variety of cellular activities in human body, such as cell proliferation, epithelial-mesenchymal transition, autophagy, etc. More and more studies have shown that its abnormal expression is associated with the occurrence, development and poor prognosis of a variety of cancers and other diseases, and LSD1 is a key regulatory factor. As a result, a number of drugs targeting LSD1 are being studied in clinical trials. Howerer, most of these inhibitors are based on blocking their demethylase activity. Recent studies show that LSD1 is also involved in a series of protein-protein interactions that are independent of its demethylation function. This greatly expands the scope of its biological function and provides new strategies and directions for the design of LSD1 inhibitors. Based on the current literatures, this paper summarize the research progress of function of LSD1 and discuss its application prospect.
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2021, Vol. 18 
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