经导管主动脉瓣置换术术后患者的中医证候探索性研究

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摘要目的探讨经导管主动脉瓣置换术（TAVR）术后患者的中医证候分布。方法选择2018年1月—2019年1月于中国医学科学院阜外医院成功行TAVR治疗的70例老年重度主动脉瓣狭窄患者，采集患者的症状及理化指标，进行聚类分析，结合临床归纳出主要证型。结果 TAVR术后患者中医症状出现频数位列前十的是倦怠乏力（88.6%）、活动后气短（77.4%）、活动后心悸（77.1%）、口干少津（70.0%）、神疲懒言（60.0%）、舌苔白腻（57.1%）、胸胁刺痛（55.7%）、心慌胸闷（54.3%）、活动后汗出（52.9%）、舌质暗红（52.9%）。聚类分析结果显示，中医证候可归纳为阳虚证，气阴两虚证，气血两亏、瘀阻水停证。结论 TAVR术后患者的中医证候以阳虚证，气阴两虚证，气血两亏、瘀阻水停证为主，为中医药治疗提供理论依据。

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	于子凯1 吴永健2▲ 陈可冀1▲

关键词 ：经导管主动脉瓣置换术, 聚类分析, 中医证型, 主动脉瓣狭窄

Abstract：Objective To explore the distribution of traditional Chinese medicine syndromes in patients after transcatheter aortic valve replacement (TAVR). Methods Seventy elderly patients with severe aortic stenosis who were successfully treated with TAVR in Fuwai Hospital, Chinese Academy of Medical Sciences from January 2018 to January 2019 were selected. The symptoms and physicochemical indexes of patients were gathered, and the main syndromes were concluded according to the clinical data by using cluster analysis. Results The top ten traditional Chinese medicine syndromes symptoms of patients after TAVR were tiredness and weakness (88.6%), shortness of breath after exercise (77.4%), palpitation after exercise (77.1%), dry mouth (70.0%), spiritlessness and lazy speech (60.0%), white and greasy fur (57.1%), stabbing pain in chest and hypochondrium (55.7%), palpitation and oppression in chest (54.3%), sweating after activity (52.9%), dark red tongue (52.9%). The results of cluster analysis showed that traditional Chinese medicine syndromes can be summarized as yang deficiency syndrome, syndrome of deficiency of both qi and yin, qi and blood deficiency, blood stasis and water stagnation syndrome. Conclusion Traditional Chinese medicine syndromes of patients after TAVR operation are mainly yang deficiency syndrome, qi and yin deficiency syndrome, qi and blood deficiency, blood stasis and water stagnation syndrome. It provides a theoretical basis for the treatment of traditional Chinese medicine

Key words： Transcatheter aortic valve replacement Cluster analysis Traditional Chinese medicine syndrome Aortic stenosis

基金资助:中国中医科学院博士研究生创新人才培养基金项目（CX201903）。

通讯作者: ▲共同通讯作者

引用本文:

于子凯1 吴永健2▲ 陈可冀1▲. 经导管主动脉瓣置换术术后患者的中医证候探索性研究[J]. 中国医药导报, 2021, 18(3): 173-176.
YU Zikai1 WU Yongjian2▲ CHEN Keji1▲. Exploration study on traditional Chinese medicine syndrome of patients after transcatheter aortic valve replacement. 中国医药导报, 2021, 18(3): 173-176.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2021/V18/I3/173

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