Abstract：Objective To investigate the diagnostic value of the uterine epithelial cells stability of the cells free ferrous protoporphyrin (FH) for cervical cancer. Methods Three hundred and three female patients with cervical cancer screening in Brain Hospital of Hunan Province were selected from February 2014 to December 2016, and there were 56 cases of cervical cancer and 112 cases of cervical intraepithelial neoplasia Ⅱ-Ⅲ (CIN Ⅱ-Ⅲ) by pathological diagnosis and 135 cases of normal healthy women by cervical scraping smear test, who were detected by uterine epithelial cells stability FH test and thinprep cytologic test (TCT). The pathological diagnosis was used as the gold standard, and the sensitivities, specificity, accuraciy, Youden indexes, positive and negative predictive values of the uterine epithelial cells stability FH and TCT for cervical cancer and CINⅡ-Ⅲ were analyzed. Results The total FH positive rate of cervical cancer patients and CIN Ⅱ-Ⅲ patients were significantly higher than that of normal healthy subjects (P < 0.05), of which the patients with cervical cancer were significantly higher than of the CINⅡ-Ⅲ patients (P < 0.05). There were 54 cases patients of cervical cancer and 97 patients of CIN Ⅱ-Ⅲ who were detected by uterine epithelial cells stability FH, and there were 49 patients of cervical cancer and 93 patients of CINⅡ-Ⅲ who were detected by TCT. The sensitivities, specificity, accuracies, Youden indexes, positive predictive value and negative predictive value of the uterine epithelial cells stability FH test were higher than those of the TCT. Conclusion The expressions of the uterine epithelial cells stability FH test are increased in cervical cancer, which has higher accuracies, sensitivity, specificity, positive and negative predictive values for the detection of cervical cancer.
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2018, Vol. 15 
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