Logistic regression analysis of early neurological deterioration in patients with acute cerebral infarction
WANG Xiaojing1 LU Bo1 HE Ni’na1 LYU Zhikun1 LI Guozhen1 ZHAO Chuanqing1 SHEN Danping2
1.The Second Department of Neurology, Baoding Second Central Hospital, Hebei Province, Baoding 072750, China;
2.Department of Imaging, Baoding Second Central Hospital, Hebei Province, Baoding 072750, China
Abstract：Objective To investigate the risk factors of early neurological deterioration (END) after intravenous thrombolysis for acute cerebral infarction. Methods A total of 152 patients with acute cerebral infarction treated by intravenous thrombolysis with Alteplase from March 2016 to December 2019 in the Department of Neurology, Baoding Second Central Hospital were selected as the research objects. According to whether the patients presented END after thrombolytic therapy, they were divided into END group (28 cases) and no-END group (124 cases). Basic data of each study object were collected, and risk factors of END were analyzed by univariate and multivariate logistic regression analysis. Results The proportions of diabetes history and ischemic stroke history in the END group were higher than those in the no-END group (P ＜ 0.05). There were significant differences in infarct site, degree of responsible vessel stenosis and trial of Org10172 in acute stroke treatment (TOAST) type between the two groups (P ＜ 0.05). Diabetes history, ischemic stroke history, cardiogenic embolism and large artery atherosclerosis were all independent risk factors of END in patients with acute cerebral infarction after thrombolytic therapy (OR = 4.832, 2.542, 1.854, 1.679, P ＜ 0.05). Conclusion People with history of diabetes and ischemic stroke, and TOAST type with cardiogenic embolism and large artery atherosclerosis are at higher risk of developing END.
2021, Vol. 18 
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