Abstract:Preeclampsia as a group of hypertensive disorders during pregnancy, is one of the four leading causes of maternal death. Adequate vitamin D levels play an important role in maternal and child health during pregnancy. Vitamin D is closely associated with the onset of preeclampsia. Its mechanism is mainly related to oxidative stress, immunity, blood pressure regulation and epigenetics. Vitamin D supplementation can reduce the incidence of pregnancy complications, reduce the risk of preeclampsia, and improve adverse pregnancy outcomes. Future high-quality clinical studies are needed to confirm the benefits of vitamin D supplementation for preeclampsia. Vitamin D supplementation may be an effective intervention strategy to prevent preeclampsia.
苑程鲲 鲁彩霞. 维生素D与子痫前期发病的相关性研究进展[J]. 中国医药导报, 2021, 18(1): 40-43.
YUAN Chengkun LU Caixia. Progress of the correlation between vitamin D and preeclampsia. 中国医药导报, 2021, 18(1): 40-43.
[1] Cicero AF,Degli Esposti D,Immordino V,et al. Independent determinants of maternal and fetal outcomes in a sample of pregnant outpatients with normal blood pressure,chronic hypertension,gestational hypertension and preeclampsia [J]. Clin Hypertens,2015,17(10):777-782.
[2] Staff AC,Johnsen GM,Dechend R,et al. Preeclampsia and uteroplacental acute atherosis:Immune and inflammatory factors [J]. J Reprod Immunol,2014,3:101-126.
[3] Wheeler BJ,Taylor BJ,de Lange M,et al. A longitudinal study of 25-hydroxy vitamin D and parathyroid hormone status throughout pregnancy and exclusive lactation in New Zealand mothers and their infants [J]. Nutrients,2018, 10(1):e86.
[4] Xin Z,Rui F,Renqiang Y,et al. Maternal Vitamin D Status in the Late Second Trimester and the Risk of Severe Preeclampsia in Southeastern China [J]. Nutrients,2017, 9(2):138.
[5] Heyden EL,Wimalawansa SJ. Vitamin D:effects on human reproduction,pregnancy and fetal wellbeing [J]. Steroid Biochem Mol Biol,2018,180:41-50.
[6] Koster MPH,van Duijn L,Krul-Poel YHM,et al. A compromised maternal vitamin D status is associated with congenital heart defects in off spring [J]. J Early Hum Dev,2018,117:50-56.
[7] Sparling TM,Nesbitt RC,Henschke N,et al. Nutrients and perinatal depression:a systematic review [J]. Nutr Sci,2017,6:61.
[8] Lepsch J,Eshriqui I,Farias DR,et al. Association between early pregnancy vitamin D status and changes in serum lipid profiles throughout pregnancy [J]. Metabolism,2017, 70:85-97.
[9] Serrano Díaz NC,Gamboa Delgado EM,Domínguez Urrego CL,et al. Vitamin D and risk of preeclampsia:a systematic review and meta-analysis [J]. Biomédica,2018,38:43-53.
[10] Yingdi Y,Wen T,Pengfei X,et al. Association of maternal serum 25-hydroxyvitamin D concentrations with risk of preeclampsia:a nested case-control study and meta-analysis [J]. J Matern Fetal Neonatal Med,2019, 7:1-10.
[11] Nema J,Sundrani D,Joshi S,et al. Role of vitamin D in influencing angiogenesis in preeclampsia [J]. Hypertens Pregnancy,2019,38(4):201-207.
[12] Wimalawansa SJ. Vitamin D Deficiency:Effects on Oxidative Stress,Epigenetics,Gene Regulation,and Aging [J]. Biology (Basel),2019,8(2):30.
[13] Jeffery LE,Burke F,Mura M,et al. 1,25-dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and Fox P3 [J]. Immunol,2009,183(9):5458-5467.
[14] Tangeras LH,Austdal M,Skrastad RB,et al. Distinct first trimester cytokine profiles for gestational hypertension and preeclampsia [J]. Arterioscler Thromb Vasc Biol,2015,35(11):2478-2485.
[15] Barrera D,Diaz L,Noyola Martinez N,et al. Vitamin D and inflammatory cytokines in healthy and preeclamptic pregnancies [J]. Nutr ients,2015,7(8):6465-6490.
[16] La Marca BD,Ryan MJ,Gilbert JS,et al. Inflammatory cytokines in the pathophysiology of hypertension during preeclampsia [J]. Curr Hypertens Rep,2007,9(6):480-485.
[17] Chatterjee P,Chiasson VL,Kopriva SE,et al. Interleukin 10 deficiency exacerbates toll-like receptor 3-induced preeclampsia-like symptoms in mice [J]. Hypertension,2011,58(3):489-496.
[18] Kalantar F,Rajaei S,Heidari AB,et al. Serum levels of tumor necrosis factor,interleukin-15 and interleukin-10 in patients with preeclampsia in comparison with normotensive pregnant women [J]. Iran Nurs Midwifery Res,2013,18(6):463-466.
[19] Chatterjee P,Chiasson VL,Bounds KR,et al. Regulation of the anti-inflammatory cytokines interleukin-4 and interleukin-10 during pregnancy [J]. Front Immunol,2014, 5:253.
[20] Wei S,Audibert F,Fraser W,et al. Maternal plasma 25-hydroxyvitamin D levels,angiogenic factors,and preeclampsia [J]. Obstet Gynecol,2013,208(5):390,e1-e6.
[21] Li YC,Qiao G,Uskokovic M,et al. Vitamin D:a negative endocrine regulator of the renin-angiotensin system and blood pressure [J]. Steroid Biochem Mol Biol,2004,89/90(1/5):387-392.
[22] Faulkner JL,Amaral LM,Cornelius DC,et al. Vitamin D supplementation reduces some AT1-AA-induced downstream targets implicated in preeclampsia including hypertension [J]. Physiol Regul Integr Comp Physiol,2017, 312(1):125-131.
[23] Ajabshir S,Asif A,Nayer A. The effects of vitamin D on the renin-angiotensin system [J]. J Nephropathol,2014,3(2):41-43.
[24] Behjat Sasan S,Zandvakili F,Soufizadeh N,et al. The effects of vitamin D supplement on prevention of recurrence of preeclampsia in pregnant women with a history of preeclampsia [J]. Obstet Gynecol Int,2017,2017:8249264.
[25] Dongdong Z,Cheng C,Yan W,et al. Effect of Vitamin D on Blood Pressure and Hypertension in the General Population:An Update Meta-Analysis of Cohort Studies and Randomized Controlled Trials [J]. Prev Chronic Dis,2020,9(17):1-3.
[26] B?覿rebring L,O'Connell M,Winkvist A,et al. Serum Cortisol and Vitamin D Status Are Independently Associated With Blood Pressure in Pregnancy [J]. Steroid Biochem Mol Biol,2019,189,259-264.
[27] Morvaridzadeh M,Sepidarkish M,Fazelian S,et al. Effect of Calcium and Vitamin D Co-supplementation on Blood Pressure:A Systematic Review and Meta-Analysis [J]. Clin Ther 2020,42(3):e45-e63.
[28] Wei R,Christakos S. Mechanisms Underlying the Regulation of Innate and Adaptive Immunity by Vitamin D [J]. Nutrients,2015,7(10):8251-8260.
[29] Carsten Carlberg. Vitamin D Signaling in the Context of Innate Immunity:Focus on Human Monocytes frontiers in Immunology [J]. Front Immunol,2019,10:2211.
[30] Tilstra JS,Robinson AR,Wang J,et al. NF-kappa B inhibition delays DNA damage-induced senescence and aging in mice [J]. Clin Investig,2012,122(7):2601-2612.
[31] Wang Q,He Y,Shen Y,et al. Vitamin D inhibits COX-2 expression and inflammatory response by targeting thioesterase superfamily member 4 [J]. Biol Chem,2014, 289(17):11681-11694.
[32] Naidoo Y,Moodley J,Ram suroun V,et al. Polymorphisms within vitamin D binding protein gene within a Preeclamptic South African population [J]. Hypertens Pregnancy,2019,38(4):260-267.
[33] Tamblyn JA,Hewison M,Wagner CL,et al. Immunological role of vitamin D at the maternal-fetal interface [J]. J Endocrinol,2015,224(3):114-117.
[34] C?覾mara AB,Brand?觔o IA. The Relationship Between Vitamin D Deficiency and Oxidative Stress Can Be Independent of Age and Gender [J]. Vitam Nutr,2019, 11(12):1-16.
[35] Yinn F,Sancheti H,Patil I,et al. Energy metabolism and inflammation in brain aging and Alzheimer’s disease [J]. Free Radic Biol Med,2016,100:108-122.
[36] Abbasalizadeh S,Abam F,Mirghafourvand M,et al. Comparing levels of vitamin D,calcium and phosphorus in normotensive pregnant women and pregnant women with preeclampsia [J]. J Obstet Gynaecol,2019,12.
[37] Benachi A,Baptiste A,Taieb J,et al. Relationship between vitamin D status in pregnancy and the risk for preeclampsia:A nested case-control study [J]. Clin Nutr,2020,39(2):440-446.
[38] Mansoor A,Alobaid AA,Malhis TN,et al. Effect of vitamin D3 supplementation in pregnancy on risk of pre-eclampsia-Randomized controlled trial [J]. Clin Nutr Apr,2019,38(2):557-563.
[39] Zerofsky MS,Jacoby BN,Pedersen TL,et al. Daily cholecalciferol supplementation during pregnancy alters markers of regulatory immunity,inflammation,and clinical outcomes in a randomized controlled trial [J]. Nutrients,2016, 146(11):2388-2397.
[40] Fogacci S,Fogacc F,Banach M,et al. Vitamin D supplementation and incident preeclampsia:A systematic review and meta-analysis of randomized clinical trials [J]. Clin Nutr,2019,19,33027-33031.
[41] Bujold E,Hyett J. Calcium supplementation for prevention of pre-eclampsia [J]. Lancet,2019,26(393):298-300.
[42] ACOG Practice Bulletin No. 202:Gestational hypertension and preeclampsia [J]. Obstet Gynecol,2019,1(133):1-25.
[43] WHO Recommendation on Calcium Supplementation Before Pregnancy for the Prevention of Pre-Eclampsia and Its Complications [Internet]. Geneva:World Health Organization,2020.
[46] Palacios C,Trak-Fellermeier MA,Martinez RX,et al. Regimens of vitamin D supplementation for women during pregnancy (Review) [J]. Cochrane Library,2019,10(10):CD013446.