Abstract：Objective To study the effect of Dandao Paishi Mixture combined with percutaneous transhepatic cholangioscopic lithotomy (PTCSL) in the treatment of calculus of intrahepatic duct. Methods A total of 63 patients with the diagnosis of calculus of intrahepatic duct from the First Affiliated Hospital of Guangzhou University of Chinese Medicine from November 2017 to December 2018 were divided into the observation group (32 cases) and the control group (31 cases) according to the random number table method. The control group was treated with PTCSL, and the observation group was given Dandao Paishi Mixture after the treatment on the basis of the control group for six months. The number of PTCSL recurrences after surgery, the one-year recurrence rate, the volume of bile drained by the percutaneous transhepatic cholangial drainage (PTCD) tube and the degree of stone removal were compared between the two groups. Results The number of PTCSL recurrences after surgery and one-year recurrence rate in the observation group were both lower than those in the control group, the differences were statistical significance (P ＜ 0.05). The overall analysis of the two-way repeated measures variance found that the differences between groups, time point comparisons and interaction comparisons were statistically significant (all P ＜ 0.05). Intra-group comparison：Compared with the third day after surgery, the PTCD bile drainage volume increased in the observation group on the seventh day and two months after surgery, and two months after surgery was more than the seventh day after surgery, the differences were statistically significant (all P ＜ 0.05). Comparison between groups：the bile drainage volume of PTCD tube in the observation group was higher than that in the control group on the seventh day and two months after the operation, and the differences were statistically significant (all P ＜ 0.05). The degree of removal of stones in the observation group was better than that in control group, and the difference was statistically significant (P ＜ 0.05). Conclusion PTCSL can effectively remove the calculus of intrahepatic duct. The combined use of Dandao Paishi Mixture can promote bile secretion, promote stone excretion, reduce the number of operations and postoperative recurrence rate, and prevent the recurrence of stones. It is worthy of clinical application.
2020, Vol. 17 
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