Current situation and prospect on the treatment of chemotherapy-induced alopecia in breast cancer patients based on traditional Chinese medicine
WANG Zhaodongfang1 ZHOU Jialin1 LIU Sida1 WAN Donggui2
1.Beijing University of Chinese Medicine, Beijing 100029, China;
2.Department of Integrative Medicine Oncology, China-Japan Friendship Hospital, Beijing 100029, China
Abstract：Chemotherapy-induced alopecia（CIA）, as one of the frightening side effects for most breast cancer patients, has a negative effect on patients’ psychology state and compliance of treatment. Traditional Chinese medicine has unique advantages in the prevention and treatment of CIA with the theory that hair is the surplus of the blood, kidney stores the essence and has its manifestations in hair. The etiology and pathogenesis of CIA in traditional Chinese medicine are that the medicine pathogen of chemotherapeutics can cause the deficiency of both qi and blood as well as the deficiency of liver-kidney yin, thus lead to the undernutrition of hair or the stagnation of liver qi can then cause the combination of qi stagnation and blood stasis syndrome, which makes the stagnated blood lock collaterals, and the hair may also lose nourishment. So the treatment of CIA should be applied by invigorating qi and nourishing blood, tonifying liver and kidney, or promoting blood circulation to remove meridian obstruction respectively based on the traditional Chinese medicine syndrome differentiation and treatment system. Basic medical research showed that the mechanism of Chinese herbs in treating CIA is related to the inhibition of corticotropin-releasing factor receptor and prostaglandin D2 synthetase.
王照东方1 周佳琳1 刘思达1 万冬桂2. 乳腺癌化疗性脱发的中医治疗现状与展望[J]. 中国医药导报, 2020, 17(36): 49-52.
WANG Zhaodongfang1 ZHOU Jialin1 LIU Sida1 WAN Donggui2. Current situation and prospect on the treatment of chemotherapy-induced alopecia in breast cancer patients based on traditional Chinese medicine. 中国医药导报, 2020, 17(36): 49-52.
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2020, Vol. 17 
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