Analysis on the experience of Professor Wei Junping in differentiating and treating diabetic nephropathy
LI Fei1,2 WEI Junping2▲
1.Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China;
2.Department of Edocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
Abstract:Diabetic nephropathy is one of the most common capillary vessel complications of diabetes. Professor Wei Junping believes that the pathogenesis of diabetic nephropathy in traditional Chinese medicine is always based on root deficiency and branch excess. The root is the deficiency of qi and yin. The excess of branch is mainly manifested in the accumulation of pathological products, such as phlegm, blood stasis, and dampness. The zang-fu organs mainly involve the liver, spleen and kidney. In the treatment, diabetic nephropathy is combined with disease and syndrome, and it is divided into four syndrome types: deficiency of both qi and yin, internal blockade of damp-turbidity, yin deficiency of liver and kidney, yang deficiency of spleen and kidney. Professor Wei believes that diabetic nephropathy lesions involve sanjiao, and diabetic nephropathy is treated by stages, which are divided into early, middle and late periods, in order to reverse early intervention, delay progress in the middle period, and improve symptoms in the late stage. In the clinical process, by combining modern pharmacological research and medication, Professor Wei always guides the lifestyle of patients with diabetic nephropathy. And the idea of “preventive treatment of disease” of traditional Chinese medicine is used throughout the treatment process, as far as possible to delay the development process of diabetic nephropathy.
李菲1,2 魏军平2▲. 魏军平教授辨治糖尿病肾病经验分析[J]. 中国医药导报, 2020, 17(33): 157-160.
LI Fei1,2 WEI Junping2▲. Analysis on the experience of Professor Wei Junping in differentiating and treating diabetic nephropathy. 中国医药导报, 2020, 17(33): 157-160.
[1] International Diabetes Federation. IDF Diabetes Atlas [Z/OL]. 9th ed. Brussels:International Diabetes Federation,2019. http://www.diabetesatlas.org.
[2] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017年版)[J].中国实用内科杂志,2018,38(4):292-344.
[3] American Diabetes Association. Microvascular Complications and Foot Care:Standards of Medical Care in Diabetes-2020 [J]. Diabetes Care,2020,43(Suppl 1):S135-S151.
[4] Dabelea D,Stafford JM,Mayer-Davis EJ,et al. Association of Type 1 Diabetes vs Type 2 Diabetes Diagnosed During Childhood and Adolescence With Complications During Teenage Years and Young Adulthood [J]. JAMA,2017,317(8):825-835. doi:10.1001/jama.2017.0686.
[5] Issues and Events [J]. Diabetes,2019,68(6):1359.
[6] 张颖.中西医结合治疗糖尿病肾病并发蛋白尿的疗效观察[J].辽宁中医杂志,2018,45(7):1432-1435.
[7] Huang YC,Tsay HJ,Lu MK,et al. Astragalus membranaceus-Polysaccharides Ameliorates Obesity,Hepatic Steatosis,Neuroinflammation and Cognition Impairment without Affecting Amyloid Deposition in Metabolically Stressed APPswe/PS1dE9 Mice [J]. Int J Mol Sci,2017,18(12):2746. doi:10.3390/ijms18122746.
[8] 宋建波,廖晖,李元平.基于网络药理学探讨黄芪治疗糖尿病肾病作用机制[J].中草药,2020,51(11):2988-2996.
[9] Chao CL,Huang HC,Lin HC,et al. Sesquiterpenes from Baizhu Stimulate Glucose Uptake by Activating AMPK and PI3K [J]. Am J Chin Med,2016,44(5):1-17.
[10] 吴昊姝,徐建华,陈立钻,等.铁皮石斛降血糖作用及其机制的研究[J].中国中药杂志,2004,29(2):69-72.
[11] 龚频,田东,王丹妮,等.葛根醇提物对糖尿病肾病小鼠肾功能改善的研究[J].食品研究与开发,2019,40(3):19-23.
[12] Lee CW,Seo JY,Kim SL,et al. Corn silk maysin ameliorates obesity in vitro and in vivo via suppression of lipogenesis,differentiation,and function of adipocytes [J]. Biomed Pharmacother,2017,93:267-275.
[13] 平橹,孙艳艳,方敬爱,等.芡实对糖尿病肾病大鼠肾组织MMP-9、TIMP-1及Collagen Ⅳ表达的影响[J].中国中西医结合肾病杂志,2015,16(7):583-586,661-662.
[14] 仝小林,周水平,李爱国,等.水蛭对糖尿病大鼠肾脏病变的防治作用及机理探讨[J].中国中医药信息杂志,2002,9(6):21-23.
[15] 谢榆,汪悦,纪伟.朱良春应用穿山龙经验[J].山东中医杂志,2013,32(6):434-435.
[16] 金惠杰,邱昆成,李嘉华,等.药对知母-黄柏对胰岛素抵抗的改善作用[J].中国药理学通报,2019,35(7):1020-1024.
[17] 丁元庆.《兰室秘藏》应用知母黄柏之浅识[J].中医函授通讯,1995(2):14-15.
[18] Zhang M,Feng L,Gu J,et al. The attenuation of Moutan Cortex on oxidative stress for renal injury in AGEs-induced mesangial cell dysfunction and streptozotocin-induced diabetic nephropathy rats [J]. Oxid Med Cell Longev,2014,2014(1)463815. doi:10.1155/2014/463815.
[19] 高大威,李青旺,刘志伟,等.女贞子中齐墩果酸抗糖尿病效果研究[J].中成药,2009,31(10):1619-1621.
[20] 张颖,李赛,丁选胜.淫羊藿苷对糖尿病肾病大鼠肾动脉舒缩功能的影响[J].药学与临床研究,2016,24(3):209-211.
[21] 冯惠敏,王周平,徐德平.益智仁缩尿功效成分的研究[J].食品与机械,2019,35(3):172-175,181.
[22] 滕瑜,王彩理.牡蛎的营养和降糖作用研究[J].海洋水产研究,2005,26(6):39-44.
[23] 谢薇,尚进,赵占正.网络互动平台的延伸护理服务在早期糖尿病肾病患者中的应用及效果观察[J].护士进修杂志,2020,35(8):759-762.
[24] 林海丽,刘爽,黄婵娟,等.延续性干预对2型糖尿病肾病患者血糖、血脂和肾功能的影响[J].中国医师杂志,2020,22(3):451-454.
[25] 汤巍,刘娜,范莹莹.补充益生菌对老年糖尿病肾病患者疾病进展风险的影响[J].中国微生态学杂志,2020, 32(5):570-574.
[26] 胡雪丽,刘仕杰,刘洋,等.营养膳食联合认知行为疗法对老年糖尿病肾病患者的焦虑抑郁情绪、营养状况与认知功能的影响[J].国际精神病学杂志,2020,47(2):373-375,378.