生理性失眠发病机制的研究进展
独家能1 刘聪2 郝旭亮2 倪艳2 许雯雯2 季海霞2
1.山西中医药大学研究生部,山西太原 030619;
2.山西省中医药研究院中药方剂研究所,山西太原 030045
Research progress on pathogenesis of physiological insomnia
DU Jianeng1 LIU Cong2 HAO Xuliang2 NI Yan2 XU Wenwen2 JI Haixia2
1.Graduate School, Shanxi University of Chinese Medicine, Shanxi Province, Taiyuan 030619, China;
2.Shanxi Institute of Traditional Chinese Medicine, Shanxi Province, Taiyuan 030045, China
摘要 失眠是指无法入睡或无法保持睡眠状态而导致次日白天社会功能严重下降的疾病。目前主要认为生理性失眠是由脑部中枢的γ-氨基丁酸(GABA)能神经元系统功能低下、应激中枢系统的下丘脑-垂体-肾上腺轴(HPA轴)功能亢进、褪黑素(MT)分泌水平下降及细胞因子等分泌失调造成的,以及一些特异性神经递质不同程度的表达,使中枢神经系统紊乱导致失眠的发生。本文从上述几个方面对生理性失眠的发病机理进行综述总结,为治疗失眠提供新的思路。
关键词 :
生理性失眠 ,
下丘脑-垂体-肾上腺轴 ,
神经递质 ,
发病机制
Abstract :Insomnia refers to the inability to fall or stay asleep leading to a serious decline in social function during the next day. At present, physiological insomnia was mainly caused by brain gamma aminobutyric acid (GABA) neurons system dysfunction, hyperactivity of hypothalamic pituitary adrenal axis (HPA axis), melatonin (MT) secretion decline, cytokines secretion disorders and different degree expression of some specific neurotransmitters. In result of central nervous system dysfunction which leading to the occurrence of insomnia. This article summarized the pathogenesis of physiological insomnia the aspect above, aiming to provide new methods to treat insomnia.
Key words :
Psychophysiological insomnia
Hypothalamic-pituitary-adrenal axis
Neurotransmitter
Pathogenesis
基金资助: 山西省中医药研究院中药新药研究专项(2016XYZX02)
通讯作者:
郝旭亮(1975.10-),男,博士,主任药师;研究方向:中药作用物质基础及作用机理研究。
作者简介 : 独家能(1991.10-),男,山西中医药大学研究生部2015级中药学专业在读硕士研究生;研究方向:中药活性成分分析与质量控制。
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