Effects of Propranolol combined with Isosorbide Nitrate on the levels of Obestatin, tPAI-1 and Fractalkine in patients with coronary heart disease and angina pectoris
DENG Jing1 WANG Chunlian1▲ WEN Junjie2 WU Bin1
1.Department of Pharmacy, Guang’an People’s Hospital West China Guang’an Hospital of Sichuan University, Sichuan Province, Guang’an 638000, China; 2.Department of Cardiology, Guang’an People’s Hospital West China Guang’an Hospital of Sichuan University, Sichuan Province, Guang’an 638000, China
Abstract：Objective To investigate the effect of Propranolol combined with Isosorbide Nitrate on patients with coronary heart disease and angina pectoris, and the effect on levels of Obestatin, tissue-plasminogen activator inhibitor-1 (tPAI-1) and irregular chemokines (Fractalkine). Methods A total of 126 patients with coronary heart disease and angina pectoris who were treated in Guang’an People’s Hospital, Sichuan Province from April 2018 to April 2019 were selected and divided into control group and treatment group according to the random number table method, with 63 cases in each group. The control group was treated with Isosorbide Nitrate. The treatment group was treated with Propranolol combined with Isosorbide Nitrate. Both groups received continuous treatment for 14 days. The incidence of angina pectoris was observed. The cardiac functions of the two groups were examined, the serum and other relevant indicators levels were detected, and the therapeutic effect of the two groups was compared. Results After treatment, the number and duration of angina pectoris attacks in the treatment group were lower than those in the control group, and the differences were statistically significant (all P ＜ 0.05). The level of left ventricular posterior wall thickness in the treatment group was lower than that in the control group, the levels of left ventricular ejection fraction and cardiac output in the treatment group were higher than those in the control group, and the differences were statistically significant (all P ＜ 0.05). The level of serum glutathione peroxidase in the treatment group was higher than that in the control group, while lipid peroxide, malondialdehyde, Obestatin, tPAI-1, Fractalkine levels were all lower than those in the control group, and the differences were statistically significant (all P ＜ 0.05). The total effective rate of the treatment group was higher than that of the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Patients with coronary heart disease and angina pectoris treated with Pronalolol combined with Isosorbide Nitrate can improve the occurrence of angina pectoris, improve the cardiac function and antioxidant capacity, and improve the levels of serum Obestatin, tPAI-1 and Fractalkine.
邓静1 王春莲1▲ 文俊杰2 吴彬1. 普萘洛尔联合硝酸异山梨酯对冠心病心绞痛患者Obestatin、tPAI-1、Fractalkine水平的影响[J]. 中国医药导报, 2020, 17(32): 56-59.
DENG Jing1 WANG Chunlian1▲ WEN Junjie2 WU Bin1. Effects of Propranolol combined with Isosorbide Nitrate on the levels of Obestatin, tPAI-1 and Fractalkine in patients with coronary heart disease and angina pectoris. 中国医药导报, 2020, 17(32): 56-59.
2020, Vol. 17 
京公网安备 11010502046598号