Abstract:Objective To explore the value of saffron in the treatment of rehabilitation of sequela of apoplexy. Methods A total of 120 patients with sequela of apoplexy who were treated at the Baoding First Central Hospital from January 2018 to December 2019 were selected as the research objects. According to the random number table method, they were divided into the conventional group and the saffron group, with 60 cases in each group. The conventional group received routine standardized treatment, and the saffron group added saffron treatment on the basis of the conventional group. After eight weeks of treatment, the treatment effects of the two groups were compared, including the National Institutes of Health Stroke Scale (NIHSS) score, activities of daily living (ADL) score, hemorheological indicators [hematocrit, erythrocyte sedimentation rate, fibrinogen, whole blood viscosity (low cut), whole blood viscosity (high cut), platelet aggregation index] and therapeutic efficacy. Results After treatment, the NIHSS scores of the two groups were significantly lower than before treatment, and the saffron group was significantly lower than that of the conventional group (P < 0.05). After treatment, the ADL scores of the two groups were significantly higher than those before treatment; and the saffron group was significantly higher than that of the conventional group (P < 0.05). After treatment, the hematocrit, erythrocyte sedimentation rate, fibrinogen, whole blood viscosity (low cut), whole blood viscosity (high cut), platelet aggregation index and other hemorheological indicators of the saffron group were significantly lower than those of the conventional group (P < 0.05). Compared with before treatment, the hematocrit, erythrocyte sedimentation rate and fibrinogen of patients in the conventional group were significantly reduced after treatment, and all hemorheological indexes in the saffron group were significantly reduced (P < 0.05). The total effective rate of the saffron group was significantly higher than that of the conventional group (P < 0.05). Conclusion Saffron can significantly improve the neurological function of patients with sequela of apoplexy, can also improve their daily living ability and down-regulate the hemorheology indicators, such as the hematocrit, erythrocyte sedimentation, fibrinogen, whole blood viscosity (low cut), whole blood viscosity (high cut), platelet aggregation index, to improve the treatment efficiency of patients, which is worthy of clinical promotion.
温彬 康丽娟 靳丽丽. 藏红花应用于中风后遗症恢复治疗的价值[J]. 中国医药导报, 2020, 17(31): 150-153.
WEN Bin KANG Lijuan JIN Lili. The value of saffron in the rehabilitation of sequela of apoplexy. 中国医药导报, 2020, 17(31): 150-153.
[1] 孔翠明.脑中风患者后遗症偏瘫的早期康复治疗效果[J].双足与保健,2017,26(14):20-21.
[2] Thrift AG,Cadilhac DA,Thayabaranathan T,et al. Global stroke statistics [J]. Int J Stroke,2013,9(1):6-18.
[3] Wang WZ,Jiang B,Sun HX,et al. Prevalence,Incidence,and Mortality of Stroke in China [J]. Circulation,2017, 135(8):759.
[4] 吕明锐,王倩然,杨升东,等.藏红花及其组分抑制炎症因子表达的研究进展[J].重庆医学,2017,46(13):1850-1853.
[5] 陈芳,刘瑜,何敬波,等.两种藏红花浸泡液联合应用在皮肤浸渍护理中的效果观察[J].护理研究,2016,30(3):342-344.
[6] 杨寅,孙艳芳.西红花应用于补阳还五汤治疗中风后遗症的临床体会[J].医学信息:上旬刊,2011,24(7):4271-4272.
[7] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国各类主要脑血管病诊断要点2019[J].中华神经科杂志,2019,52(9):710-715.
[8] Z?觟llner,Johann Philipp,et al. National Institutes of Health Stroke Scale(NIHSS)on admission predicts acute symptomatic seizure risk in ischemic stroke:a population-based study involving 135,117 cases [J]. Sci Rep,2020, 10(1):1-7.
[9] Moore M,Vancleef K,Shalev N,et al. When neglect is neglected:NIHSS observational measure lacks sensitivity in identifying post-stroke unilateral neglect [J]. J Neurol Neurosurg Psychiatry,2019,90(9):1070-1071.
[10] Tibbett J,Widerstr?觟m-Noga EG,Thomas CK,et al. Impact of spasticity on transfers and activities of daily living in individuals with spinal cord injury [J]. J Spinal Cord Med,2019,42(3):318-327.
[11] Wakabayashi H,Matsushima M,Ichikawa H,et al. Occlusal support, dysphagia, malnutrition, and activities of daily living in aged individuals needing long-term care:A path analysis [J]. J Nutr Health Aging,2018,22(1):1-6.
[12] 唐琳.西红花(Crocussativus)7,8-二加氧酶基因(CsZCD)的克隆表达、西红花甙的药理作用及药材的鉴别研究[D].成都:四川大学,2004.
[13] Li X,Zhao Y,Hu Y,et al. Clinical efficacy of intravenous thrombolysis with alteplase in treatment of elderly patients with minor stroke and its effect on prognosis [J]. Int J Clin Exp Med,2019,12(7):9019-9029.
[14] Plummer P,Iyigün G. Effects of Physical Exercise Interventions on Dual-Task Gait Speed Following Stroke:A Systematic Review and Meta-Analysis [J]. Arch Phys Med Rehab,2018,99(12):2548-2560.
[15] 周仲瑛.出血性中风(瘀热阻窍证)证治的研究[J].中华中医药学刊,2002(6):709-711,723.
[16] 王兴.针灸与康复训练对中风后上肢痉挛性瘫痪的治疗效果[J].数理医药学杂志,2018,31(8):1252-1253.
[17] 陈娜,杨滨.西红花非药用部位化学成分和药理作用研究进展[J].中国中药杂志,2018,43(14):2884-2891.
[18] 陈欣宇,宋本华,于洪,等.西红花苷在脑卒中后抑郁大鼠中抗炎作用的研究[J].哈尔滨医科大学学报,2017, 51(3):223-227.
[19] Marcolini E,Greenberg K. Brain Trust:The NIHSS Shouldn’t Be Your Only Stroke Tool [J]. J Emerg Med,2018,40(6):1-33.
[20] 常花蕾,朱娟,于敬妮,等.藏红花素对大鼠视网膜缺血-再灌注损伤的保护作用[J].眼科新进展,2019,39(7):630-634.
[21] 金福强,张炜,杨龙,等.藏红花素对失血性休克所致器官损伤保护作用[J].医学研究杂志,2018,47(12):186-191.