Meta-analysis of combined treatment with oral Finasteride and topical Minoxidil in male androgenetic alopecia
ZHANG Shudan1 LI Qi2
1.Pharmaceutical Preparation Section, Dalian Hospital of Traditional Chinese Medicine, Liaoning Province, Dalian 116013, China;
2.Department of Internal Medicine, the Third Hospital of Wafangdian, Liaoning Province, Wafangdian 116300, China
Abstract：Objective To review systematically the curative effect and safety of combined treatment with oral Finasteride and topical Minoxidil in male androgenetic alopecia (AGA). Methods The databases of PubMed, EMbase, Cochrane Library, CBM, WanFang, CNKI and VIP were retrieved for collecting RCT and CCT about combined treatment with oral Finasteride and topical Minoxidil in AGA before March 20th 2017, and reference lists were also searched. According to the inclusion and exclusion criteria, two reviewers screened and assessed independently the potential studies, and then the data was extracted. The data was given a Meta-analysis by using RevMan 5.3 software. Results Seven study articles were included, involving 1786 patients. The Meta-analysis showed: after 3 months of treatment, the clinical curative effect of the combination group in treating AGA was better than the Minoxidil group (OR = 1.95, 95%CI: 1.37-2.76, P = 0.0002) and the Finasteride group (OR = 2.30, 95%CI: 1.64-3.23, P ＜ 0.000 01). After 6 months of treatment, the clinical curative effect of the combination group in treating AGA was better than the Minoxidil group (OR = 2.20, 95%CI: 1.26-3.84, P = 0.005) and the Finasteride group (OR = 2.50, 95%CI: 1.46-4.30, P = 0.0009). After 12 months of treatment, the clinical curative effect of the combination group in treating AGA was better than the Minoxidil group (OR = 6.83, 95%CI: 2.92-15.99, P < 0.000 01) and the Finasteride group (OR = 2.77, 95%CI: 1.77-4.32, P ＜ 0.000 01). There were no serious adverse reactions in each group. Conclusion The combination treatment of Finasteride and topical Minoxidil has significant curative effect, and the safety is good.
张树丹1 李琪2. 外用米诺地尔与口服非那雄胺联合治疗男性雄激素性秃发的Meta分析[J]. 中国医药导报, 2018, 15(1): 109-113,149.
ZHANG Shudan1 LI Qi2. Meta-analysis of combined treatment with oral Finasteride and topical Minoxidil in male androgenetic alopecia. 中国医药导报, 2018, 15(1): 109-113,149.
[1] 周镇东，汪小华，潘颖.低剂量非那雄胺与米诺地尔治疗男性雄性激素性秃发临床疗效和安全性[J].求医问药：下半月，2012（11）：999-1000.
[2] Rossi A，Anzalone A，Fortuna MC，et al. Multi-therapies in androgenetic alopecia：review and clinical experiences [J]. Dermatologic Therapy，2016，29（6）：424-432.
[3] Saraswat A. Minoxidil vs Finasteride in the Treatment of Men With Androgenetic Alopecia [J]. Archives of Dermatology，2003，139（9）：1219.
[4] Tanglertsampan C. Efficacy and safety of 3% minoxidil versus combined 3% minoxidil / 0.1% finasteride in male pattern hair loss：a randomized，double-blind，comparative study [J]. J Med Assoc Thai，2012，95（10）：1312-1316.
[5] Arca E，Acιkgöz G，Tastan H B，et al. An Open，Randomized，Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia [J]. Dermatology，2004，209（2）：117-125.
[6] 陈勇燕.米诺地尔与非那雄胺对脱发的疗效观察[J].现代诊断与治疗，2012（12）：2164.
[7] Khandpur S，Suman M，Reddy BS. Comparative efficacy of various treatment regimens for androgenetic alopecia in men [J]. J Dermatol，2002，29（8）：489-498.
[8] 陈树新，李洁华，莫玉芳.米诺地尔洗剂与非那雄胺合用治疗雄激素性脱发的临床疗效观察[J].国际医药卫生导报，2006（6）：64-65.
[9] 胡志帮，向光，向进，等.非那雄胺及米诺地尔治疗雄激素性秃发疗效分析[J].中华皮肤科杂志，2010，43（1）：58-59.
[10] 慕彰磊，柳小婧，徐峰，等.非那雄胺与米诺地尔治疗男性雄激素性秃发疗效比较[J].临床皮肤科杂志，2011， 40（6）：374-376.
[11] 王羿婷，李子海，尹晓晴，等.非那雄胺和米诺地尔治疗雄激素性秃发的临床研究[J].临床皮肤科杂志，2011， 40（7）：387-390.
[12] 杜平.非那雄胺与米诺地尔治疗男性雄性激素性秃发的疗效分析[J].河南外科学杂志，2012，18（05）：104-105.
[13] Hu R，Xu F，Sheng Y，et al. Combined treatment with oral finasteride and topical minoxidil in male androgenetic alopecia：a randomized and comparative study in Chinese patients [J]. Dermatologic Therapy，2015，28（5）：303-308.
[14] 胡瑞铭，徐峰，盛友渔，等.非那雄胺与5%米诺地尔治疗男性雄激素性秃发的疗效评估[C].2014全国中西医结合皮肤性病学术年会.南昌，2014：132.
[15] 胡瑞铭.口服非那雄胺1 mg/d、外用5%米诺地尔溶液及联合治疗男性雄激素性秃发的疗效评估及相关血清学变化[D].上海：复旦大学，2013.
[16] 胡瑞铭，徐峰，盛友渔，等.非那雄胺与5%米诺地尔治疗345例男性雄激素性秃发的疗效评估[C].中华医学会第十九次全国皮肤性病学术年会.成都，2013：720-721.
[17] Gordon H. Guyatt，Andrew D. Oxman，Victor Montori，等.GRADE指南：Ⅴ.证据质量评价——发表偏倚[J].中国循证医学杂志，2011（12）：1430-1434.
[18] Schweiger ES，Boychenko O，Bernstein RM. Update on the pathogenesis，genetics and medical treatment of patte?鄄rned hair loss [J]. J Drugs Dermatol，2010，9（11）：1412-1419.
[19] Ghanaat M. Types of hair loss and treatment options，including the novel low-level light therapy and its proposed mechanism [J]. South Med J，2010，103（9）：917-921.
[20] Orasan MS，Roman II，Coneac A，et al. Hair loss and regeneration performed on animal models [J]. Clujul Med，2016， 89（3）：327-334.
2018, Vol. 15 
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