Abstract:Objective To collect cases of premature ovarian failure (POF) treated by famous traditional Chinese medicine doctors, and to analyze the rules of formulating prescriptions, to provide reference for the selection of prescriptions and ideas for clinical treatment. Methods A computer search of proven records of famous doctors in treating POF included in the China National Knowledge Infrastructure (CNKI) database, with the subject term “premature ovarian failure” searched for documents collected from the establishment of the database until February 2020. Statistical analysis based on the frequency of drug use, nature and flavour, channel tropism of the drugs and the results of Apriori association rules as observation indicators. Results A total of 103 papers and 112 prescriptions were included, and 165 herbs were involved. The herbs listed in usage frequency from high to low were Radix Rehmanniae Preparata, Semen Cuscutae, Radix Angelicae Sinensis, Herba Epimendii, Fructus Lycii. Four nature of drugs listed from high to low were warm, clam, cold, cool, hot. The proportion of five flavors from high to low were sweet, bitter, pungent, sour, astringent, salty, tasteless. The frequency of drug used in descending order were liver, kidney, spleen, lung, heart. Apriori association rules showed that the highest rule support were Radix Rehmanniae Preparata combined with Radix Angelicae Sinensis, Radix Rehmanniae Preparata combined with Radix Angelicae Sinensis and Semen Cuscutae. Conclusion The mainly etiology of POF are deficiency of kidney and sometimes with stagnation of liver and blood stasis. The disease is intermingled deficiency and excess, mainly deficiency. The treatment principles are strengthening and nourishing marrow and essence, and combined with benefiting qi and nourishing blood, and dispersing stagnated liver qi.
李兰 钟达源 杨开锋 肖小芹. 基于名医验案探讨卵巢早衰用药规律[J]. 中国医药导报, 2020, 17(30): 165-168.
LI Lan ZHONG Dayuan YANG Kaifeng XIAO Xiaoqin. Exploration the medication rules of premature ovarian failure based on the proven records of famous doctors. 中国医药导报, 2020, 17(30): 165-168.