Abstract：Objective To observe the efficacy and safety of Modified Huangqi Chifeng Decoction in the treatment of proteinuria due to IgA nephropathy. Methods The cases came from the Outpatient Department of Nephrology in Xiyuan Hospital, China Academy of Chinese Medical Sciences from December 2011 to December 2012. 5 cases of patients with IgA nephropathy with mild to moderate proteinuria, normal kidney function and syndrome of blood stasis due to qi deficiency were enrolled. By using single case randomized controlled design, Modified Huangqi Chifeng Decoction combined with Telmisartan was applied in the treatment period and single Telmisartan was applied in the control period. The efficacy indices were 24-hour urine protein quantification and TCM symptom scores, the safety indices were liver and kidney function and blood routine examination. Results The TCM symptom scores of each case in the treatment period were significantly reduced in different degrees compared with those of control period (P ＜ 0.05); after TCM symptom scores of 5 patients were integrated, the treatment period was significantly improved compared with those of control period (P ＜ 0.05). The 24-hour urine protein quantification of each patient in the treatment period was significantly lower than those of control period (P ＜ 0.05), after 24-hour urine protein quantification of 5 patients was integrated, the treatment period was significantly less than that of control period (P ＜ 0.05). Conclusion Modified Huangqi Chifeng Decoction in treatment of proteinuria due to IgA nephropathy is safe and effective, and it is feasible to use single case randomized control design in clinical research of TCM.
焦志娜 赵明明 张昱▲ 李刘生 司远. 加味黄芪赤风汤治疗IgA肾病蛋白尿的单病例随机对照研究[J]. 中国医药导报, 2018, 15(1): 95-98.
JIAO Zhina ZHAO Mingming ZHANG Yu▲ LI Liusheng SI Yuan. Single case randomized controlled research of Modified Huangqi Chifeng Decoction in the treatment of proteinuria due to IgA nephropathy. 中国医药导报, 2018, 15(1): 95-98.
2018, Vol. 15 
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