Abstract：Objective To analyze the adverse drug reactions (ADR) caused by the anti-tuberculosis drugs, and to provide the reference for the rational use of the tuberculosis. Methods A retrospective study was conducted to collect 125 ADR cases of anti-tuberculosis drugs reported by the First Affiliated Hospital of Guangxi Medical University from 2012 to 2018. The gender, age, occurrence time of ADR, types of suspected drugs, route of administration, ADR related systems and clinical manifestations in the reports were statistically analyzed. Results ADR reports were mainly male patients, accounting for 64.80%; most ADRs occurred within 30 days after administration, accounting for 96.80%; the suspicious drugs causing ADR were Isoniazid Tablets, Isoniazid Injection, Isoniazid Aminosalicylate Tablets, Rifampicin Tablets, Rifapentine Capsules, Pyrazinamide Tablets, Ethambutol Tablets, Streptomycin Sulfate for injection, Levofloxacin Capsules; the ADR caused by oral preparation was more, accounting for 96.80%; the main ADR caused by various antituberculosis drugs was urinary system damage, the main clinical manifestation was hyperuricemia, accounting for 45.60%, followed by hepatobiliary system damage, accounting for 21.60%; there were nine cases of severe ADR, accounting for 7.20%; 81 cases of ADR patients had good prognosis, accounting for 64.80%. Conclusion Clinical medical workers should pay attention to the monitoring and treatment of ADR from anti-tuberculosis drug, adjust the medication plan when necessary, and promote rational use of drug.
2020, Vol. 17 
京公网安备 11010502046598号