鸡蛋过敏患者外周血清中半乳糖凝集素-3的表达及与鸡蛋特异性IgE的相关性

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摘要目的探讨鸡蛋过敏患者血清半乳糖凝集素-3（Gal3）与鸡蛋特异性IgE含量的相关性，为临床鸡蛋过敏提供新途径。方法筛查2016年4月～2017年4月于华中科技大学同济医学院附属同济医院过敏反应科就诊的食物过敏患者，根据患者病史、皮肤点刺试验、鸡蛋特异性IgE数值和食物排除法筛选68例鸡蛋过敏且无其他疾病患者作为鸡蛋过敏组，其中症状包含严重过敏性休克、特异性皮炎、慢性荨麻疹、轻度皮炎伴搔痒、过敏性哮喘、变应性咳嗽和过敏性鼻炎。选取同期就诊的20名无过敏病史、皮肤点刺试验及鸡蛋血清特异性IgE为阴性者作为健康对照组。分析不同症状的鸡蛋过敏患者血清中Gal3的表达及与鸡蛋特异性IgE含量的相关性。结果血清Gal3在对照组中平均浓度为（4.23±0.53）ng/mL，鸡蛋过敏组中平均浓度为（9.95±6.31）ng/mL，两组间差异有统计学意义（P = 0.0032）；各组症状中Gal3的表达量分别为：过敏性休克组为（17.21±2.54）ng/mL，过敏性哮喘组为（10.95±1.97）ng/mL，与对照组比较差异均有显著统计学意义（P = 0.0007、0.0001）；慢性荨麻疹组为（6.71±2.13）ng/mL，过敏性鼻炎组为（7.24±1.75）ng/mL，与对照组比较差异均有统计学意义（P = 0.038、0.022），而特异性皮炎组（5.04±0.15）ng/mL，变异性咳嗽组（3.24±2.75）ng/mL，轻度皮炎伴搔痒组（4.24±1.33）ng/mL，与对照组比较差异均无统计学意义（P = 0.156、0.354、0.282）；鸡蛋过敏患者血清Gal3表达与血清中鸡蛋特异性IgE含量呈显著正相关（r = 0.5932），各组临床表现症状中过敏性哮喘、过敏性鼻炎和慢性荨麻疹与特异性IgE含量呈正相关（r = 0.7792，0.8658，0.8091均P < 0.01），其余症状中Gal3表达与特异性IgE含量无明显相关性（P > 0.05）。结论 Gal3在以过敏性哮喘、过敏性鼻炎和慢性荨麻疹为表现的过敏患者中，外周血清中数值的升高表示能够提示患者存在鸡蛋过敏。

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	张书辰杨林胡林涛杨永仕祝戎飞

关键词 ：半乳糖凝集素-3, 鸡蛋过敏, 食物过敏, 特异性IgE

Abstract：Objective To detect the expression of galectin-3(Gal3) in serum of patients with egg allergy and the correlation with egg-specific IgE. Methods Screening 68 patients with egg allergy according to the history of allergy, prick test, egg-specific IgE and food exclusion from April 2016 to April 2017 in Department of Allergy of Tongji hospital Affiliated to Tongji Medical College of Huazhong University of Science & Technology. The patients with egg allergymanifested withanaphylactic shock, eczema, chronic urticaria, mild dermatitis, allergic asthma, cough variant asthma and allergic rhinitis were selected as egg allergy group. Twenty patients with no history of allergies, skin prick test and egg serum specific IgE were negative were selected as healthy controlsin the same period. The correlation between Gal3 expression and egg-specific IgE in patients with different symptoms was analyzed. Results The average concentration of Gal3 in serum of control group was (4.23±0.53) ng/mL, the average concentration of Gal3 in serum of egg allergy group was(9.95±6.31)ng/mL. The difference was statistically significant (P = 0.0032). The expression of Gal3 in each group: the concentration of Gal3 in anaphylactic shock group was (17.11±2.54) ng/mL and allergic asthma was (10.95±1.97) ng/mL significant higher than those of control group, the difference was statistically significant (P= 0.0007, 0.0001); the group of chronic urticaria was (6.71±2.13) ng/mL and allergic rhinitis was(7.24±1.75) ng/mL, compared with the control group, the differences were statistically significant (P = 0.038, 0.022); the eczema group (5.04±0.15) ng/mL, mild dermatitis group was(4.24±1.33) ng/mL and cough variant asthma group was (3.24±2.75) ng/mL, the differences were not statistically significant(P = 0.156, 0.354, 0.282 respectively). The expression of Gal3 was positively correlated with egg-specific IgE in serum (r = 0.5932). There was a positive correlation among allergic asthma, allergic rhinitis and cough variant asthma in patients with egg-specific IgE (r = 0.7792, 0.8658, 0.8091, all P < 0.01), but there was no significant difference between Gal3 expression and egg-specific IgE in the other symptoms (P > 0.05). Conclusion The expression of Gal3 in serum of patients with allergic asthma, allergic rhinitis and chronic urticaria was significantly increased, which can prompt allergy patients provoked by egg.

Key words： Galectin-3 Egg allergy Foodallergy Specific IgE

通讯作者: 祝戎飞（1980-），男，博士，副主任医师；研究方向：过敏性疾病与临床免疫。

作者简介: 张书辰（1983-），男，博士，住院医师；研究方向：食物过敏的基础与临床研究。

引用本文:

张书辰杨林胡林涛杨永仕祝戎飞. 鸡蛋过敏患者外周血清中半乳糖凝集素-3的表达及与鸡蛋特异性IgE的相关性[J]. 中国医药导报, 2018, 15(1): 64-67.
ZHANG Shuchen YANG Lin HU Lintao YANG Yongshi ZHU Rongfei. The expression of galectin-3 in serum of patients with egg allergy and its correlation with egg-specific IgE. 中国医药导报, 2018, 15(1): 64-67.

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