周细胞在缺血性脑卒中的作用机制进展

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摘要脑周细胞是神经血管单元的重要组成部分，近年来关于脑缺血的研究重点逐渐从神经元转移到神经血管单元。周细胞位于神经血管单元的中心，近年来成为新兴研究领域中的焦点。脑周细胞通过整合、处理邻近细胞的信号产生反应，发挥多种功能，包括调节血脑屏障、调节脑血流、调节免疫炎症反应、参与血管生成、调控干细胞活性以及表观遗传调控等。本文通过检索近年来国内外相关文献，探讨周细胞在缺血性脑卒中的功能和作用机制，为缺血性脑卒中机制研究提供参考，为发现新的治疗靶点提供思路。

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	彭拥军1 李文倩1 吕鹤群2 徐疏影1 吴旭1 朱冰梅3

关键词 ：缺血性脑卒中, 周细胞, 神经血管单元, 血脑屏障

Abstract：Cerebral pericytes are an important part of neurovascular units. In recent years, the focus of research on cerebral ischemia has gradually shifted from neurons to neurovascular units. Pericytes are located in the center of neurovascular units and have become the focus of new research fields in recent years. Pericerebral cells perform a variety of functions by integrating and processing the signals of neighboring cells, including regulating the blood-brain barrier, regulating cerebral blood flow, regulating immune inflammatory response, participating in angiogenesis, regulating stem cell activity and epigenetic regulation. By reviewing the relevant literature at home and abroad in recent years, this paper discusses the function and mechanism of pericytes in ischemic stroke, so as to provide reference for the study of the mechanism of ischemic stroke and provide ideas for the discovery of new therapeutic targets.

Key words： Ischemic stroke Pericytes Neurovascular units Blood-brain barrier

基金资助:国家自然科学基金资助项目（81973932、815740 60、81001556）；
中国博士后科学基金项目（2015M571790）；
全国老中医药专家学术经验继承人项目（国中医药人教发〔2017〕29号）。

通讯作者: 朱冰梅（1964-），女，教授，博士生导师；研究方向：针灸治病机制。

作者简介: 彭拥军（1977-），男，医学博士，博士后，主任中医师，博士生导师；研究方向：针灸治疗脑血管疾病及变态反应性疾病。

引用本文:

彭拥军1 李文倩1 吕鹤群2 徐疏影1 吴旭1 朱冰梅3. 周细胞在缺血性脑卒中的作用机制进展[J]. 中国医药导报, 2020, 17(29): 29-32.
PENG Yongjun1 LI Wenqian1 LYU Hequn2 XU Shuying1 WU Xu1 ZHU Bingmei3. Progress in the mechanism of pericytes in ischemic stroke. 中国医药导报, 2020, 17(29): 29-32.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2020/V17/I29/29

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