姜黄素抗衰老作用及分子机制研究新进展

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摘要姜黄素是从传统中药姜黄中提取的多酚类活性成分，长期作为中药及调味品在国内外广泛使用。因作用靶点多样，具有抗氧化、抗炎、抗动脉粥样硬化、抗肿瘤等多种作用。近年来其抗衰老作用备受研究者关注。本文主要从分子角度总结近5年姜黄素在神经系统、心血管系统及皮肤的抗衰老作用，为药物研发及合理应用提供可借鉴的思路。

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	张萌李潭林韬徐东辰龚冬梅

关键词 ：姜黄素, 抗衰老, 氧化应激, 炎症

Abstract：Curcumin is a polyphenolic active ingredient extracted from the traditional Chinese medicine Turmeric, which has been widely used as medicine and seasoning at home and abroad. Due to its multiple targets, it has various effects such as anti-oxidation, anti-inflammation, anti-atherosclerosis, anti-tumor and so on. In recent years, its anti-aging effect has attracted much attention from researchers. This review mainly summarizes the anti-aging effects of curcumin on nervous system, cardiovascular system and skin from a molecular perspective in the recent five years, expecting to shed new light on prospective drug discovery and rational application.

Key words： Curcumin Anti-aging Oxidative stress Inflammation

基金资助:国家自然科学基金资助项目（81202523）。

通讯作者: 龚冬梅（1973-），女，博士，教授，硕士生导师；研究方向：心血管药理学、抗衰老药物研究。

作者简介: 张萌（1995-），女，哈尔滨医科大学2017级药理学专业在读硕士研究生；研究方向：抗衰老药物作用及机制。

引用本文:

张萌李潭林韬徐东辰龚冬梅. 姜黄素抗衰老作用及分子机制研究新进展[J]. 中国医药导报, 2020, 17(28): 40-43.
ZHANG Meng LI Tan LIN Tao XU Dongchen GONG Dongmei. Recent progress on anti-aging and molecular mechanisms of curcumin. 中国医药导报, 2020, 17(28): 40-43.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2020/V17/I28/40

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