子痫前期患者分娩前后血清中血管紧张素原水平变化及意义

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摘要目的观察子痫前期患者分娩前后血清中血管紧张素原（AGT）水平变化及意义。方法选取2018年3月—2019年1月于河北省唐山市妇幼保健院（以下简称“我院”）产科住院择期剖宫产的子痫前期患者95例为病例组，随机选取同期于我院产科住院无指征要求剖宫产的正常孕晚期妇女60例为对照组，采用酶联免疫吸附法检测两组分娩前和分娩后72 h血清AGT水平。结果两组年龄、孕龄比较，差异无统计学意义（P > 0.05）。病例组体重指数、收缩压、舒张压高于对照组，差异有统计学意义（P ＜ 0.05）。病例组分娩前血清AGT水平高于分娩后及对照组，差异有统计学意义（P < 0.05）。病例组血清AGT水平异常的比例高于对照组，差异有统计学意义（P < 0.05）。病例组发生AGT水平异常的危险性是对照组的35.538倍，95%CI为14.422～100.235。结论子痫前期患者分娩前血清AGT水平显著增加，分娩后迅速下降，AGT在子痫前期发病中起重要作用。

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	李静左金玲张晓欲王春爽陈宝丽易建平

关键词 ：妊娠期并发症, 子痫前期, 血管紧张素原, 妊娠期高血压疾病

Abstract：Objective To observe changes and significance of serum angiotensinogen (AGT) levels in patients with preeclampsia before and after delivery. Methods Ninety-five preeclampsia patients hospitalized in Obstetrics Department of Tangshan Maternal and Child Health Hospital in Hebei Province (hereinafter referred to as “our hospital”) from March 2018 to January 2019 were selected as case group. Sixty cases of normal late pregnancy women hospitalized in Obstetrics Department of our hospital at the same time without indications for cesarean section were randomly selected as control group. The serum AGT levels between two groups were detected by enzyme linked immunosor-bent assay before and 72 h after delivery. Results There were no significant differences in age and gestational age between two groups (P > 0.05). The body mass index, systolic blood pressure and diastolic blood pressure in case group were higher than those in control group (P < 0.05). The serum AGT level of case group before delivery was higher than that after delivery and control group, the differences were statistically significant (P < 0.05). The proportion of abnormal serum AGT level in case group was higher than that in control group (P < 0.05). The risk of abnormal AGT level in case group was 35.538 times the control group, and 95%CI was 14.422-100.235. Conclusion The level of serum AGT in patients with preeclampsia increased singnificantly, fell rapidly to normal standard after childbirth, AGT maybe plays an important role in the preeclampsia.

Key words： Pregnancy complication Preeclampsia Angiotensinogen Hypertensive disorder complicating pregnancy

基金资助:河北省医学科学研究课题（20191551）。

通讯作者: 左金玲（1985.11-），女，硕士；研究方向：高危妊娠。

作者简介: 李静（1976.9-），女，硕士，副主任医师；研究方向：高危妊娠。

引用本文:

李静左金玲张晓欲王春爽陈宝丽易建平. 子痫前期患者分娩前后血清中血管紧张素原水平变化及意义[J]. 中国医药导报, 2020, 17(27): 108-111,119.
LI Jing ZUO Jinling ZHANG Xiaoyu WANG Chunshuang CHEN Baoli YI Jianping. Changes and significance of serum angiotensinogen levels in patients with preeclampsia before and after delivery. 中国医药导报, 2020, 17(27): 108-111,119.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2020/V17/I27/108

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