The effect of Probucol on diabetic nephropathy in type 2 diabetic rats
CHENG Lilan1 HUANG Jinhua2 MA Aijiang1 QI Shan1 JIN Sumin1 ZUO Songbo1
1.Department of Internal Medcine, the Second Clinic Department Directly Under the Authourity of Hebei Province, Hebei Province, Shijiazhuang 050051, China;
2.Department of Endocrinology, Beijing Zhongguancun Hospital, Beijing 100190, China
Abstract：Objective To explore the effect of Probucol on diabetic nephropathy in type 2 diabetic rats. Methods Sixteen diabetic rats were divided into DM group and PB group, 8 rats in each group. 9 normal rats were chosen as normal control group (NC group). The UMA, BUN, Scr, HOMA-IR, renal hypertrophy index, TG, TC, LDL-C, SOD, GSH-PX, MDA and Pathologic histology were selected as detected indicators. The effect of Probucol on diabetic nephropathy in type 2 diabetic rats were evaluated. Results In DM group, BUN, UMA, renal hypertrophy index, HOMA-IR, Scr, TG, TC, LDL-C, MDA were significantly higher than those of the NC group, SOD and GSH-PX were significantly lower than those of the NC group (P < 0.05 or P < 0.01). In PB group, BUN, Scr, UMA, TC, LDL-C, MDA were significantly lower than DM group, SOD and GSH-PX were significantly higher than DM group (P < 0.05or P < 0.01). The changes of renal pathological structure in PB group was significantly severer than DM group. Conclusion Probucol may play a role in diabetic nephropathy.
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2018, Vol. 15 
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