Difference analysis of clinical characteristics of polycystic ovary syndrome patients with different body mass index
YU Jinglu1 HOU Lihui2 SUN Miao2 WANG Ying2
1.Graduate School, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150036, China;
2.the Second Department of Gynecology, the First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150036, China
Abstract：Objective To study clinical characteristics, sex hormone level, glucose metabolism level and lipid metabolism level of polycystic ovary syndrome (PCOS) patients with different body mass index (BMI), and to explore the effect of obesity on PCOS. Methods From January 2015 to August 2018, 660 patients with PCOS were selected from Gynecology Clinic in the First Affiliated Hospital of Heilongjiang University of Chinese Medicine. According to different BMI, the patients were divided into normal group (BMI 18.5-＜23.0 kg/m2) of 243 cases, overweight group (BMI 23.0-＜25.0 kg/m2) of 100 cases, obesity group (BMI ≥ 25 kg/m2) of 317 cases. Clinical characteristics, sex hormone, glucose and lipid metabolism were compared among three groups. Results There were no significant differences in age and hirsutism among three groups (P > 0.05). There were significant differences in systolic blood pressure, diastolic blood pressure, waist circumference, hip circumference, waist hip ratio, acne and black acanthosis among three groups (P < 0.05). The levels of follicle stimulating hormone, luteinizing hormone, follicle stimulating hormone/luteinizing hormone, testosterone, rostenedione and sex hormone binding globulin were significantly different among three groups (P < 0.05). There were no significant differences in estradiol and dehydroepiandrosterone sulfate among three groups (P > 0.05). There were significant differences in fasting blood glucose, fasting insulin and insulin resistance index among three groups (P < 0.05). There were significant differences in triglyceride, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol among three groups (P < 0.05). Conclusion In obese PCOS patients, fat distribution is abdominal obesity, androgen level is higher, glucose and lipid metabolism disorder is more obvious.
于婧璐1 侯丽辉2 孙淼2 王颖2. 不同体重指数的多囊卵巢综合征患者的临床特征差异性分析[J]. 中国医药导报, 2020, 17(26): 75-78.
YU Jinglu1 HOU Lihui2 SUN Miao2 WANG Ying2. Difference analysis of clinical characteristics of polycystic ovary syndrome patients with different body mass index. 中国医药导报, 2020, 17(26): 75-78.
[1] March WA. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria [J]. Hum Reprod，2010，25（2）：544-551.
[2] Al-Jefout M，Alnawaiseh N，Al-Qtaitat A. Insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes [J]. Sci Rep，2017， 7（1）：5339.
[3] Legro RS，Arslanian SA，Ehrmann DA，et al. Diagnosis and treatment of polycystic ovary syndrome：an endocrine society clinical practice guideline [J]. J Clin Endocrinol Metab，2013，98（12）：4565-4592.
[4] Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome （PCOS） [J]. Hum Reprod，2004，19（1）：41-47．
[5] Douketis JD，Paradis G，Keller H，et al. Canadian guideline for body weight classification in adults：application in clinical practice to screen for overweight and obesity and to assess disease risk [J]. CMAJ，2005，172（8）：995-998.
[6] Harrison RF，Mansfield MD. Maternal plasma androgens in early human pregnancy [J]. Br J Obstet Gynaecol，2014， 87（8）：695-704.
[7] 中华医学会糖尿病分会.中国2型糖尿病防治指南（2013年版）[J].中国糖尿病杂志，2014，22（8）：2-24.
[8] 刑小燕，杨文英，杨兆军.胰岛素抵抗指数在不同糖耐量人群中诊断代谢综合征的作用[J].中国糖尿病杂志，2004， 12（3）：182-186.
[9] Nadir A，Temizkan S，Ozderya A，et al. Dehydroepiandrosterone sulfate/free androgen index ratio predicts a favorable metabolic profile in patients with polycystic ovary syndrome [J]. Gynecol Endocrinol，2019，35（2）：128-132.
[10] Alvarez-Blasco F，Botella-Carretero JI，San Millan JL，et al. Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women [J]. Arch Intern Med，2006，166（19）：2081-2086.
[11] 许娟，左玉.不同体质量指数多囊卵巢不孕患者性激素、SHBG、胰岛素、血脂水平对比分析[J].中国性科学，2017，26（12）：96-99.
[12] Role of insulin-like growth factors in initiation of follicle growth in normal and polycystic human ovaries [J]. Clin Endocrinol Metab，2013，98（8）：3298-3305．
[13] Escobar-Morreale HF，Botella-Carretero JI，Villuendas G，et al. Serum interleukin-18 concentrations are increased in the polycystic ovary syndrome：relationship to insulin resistance and to obesity [J]. J Clin Endocrinol Metab，2004，89（2）：806-811.
[14] 王君，刘月合，王春佟.多囊卵巢综合征患者性激素结合球蛋白水平与糖脂代谢相关性[J].中国计划生育杂志，2019，27（6）：764-767.
[15] 刘颖华，侯丽辉，徐芳，等.不同性激素结合球蛋白水平对多囊卵巢综合征患者的影响[J].实用医学杂志，2016，32（12）：1969-1971.
[16] 林金芳，李昕，苏椿淋.多囊卵巢综合征患者胰岛素抵抗的诊断方法及治疗策略[J].中国实用妇科与产科杂志，2007，23（9）：663-667.
[17] Manneras-Holm L，Leonhardt H，Kullberg J，et al. Adipose tissue has aberrant morphology and function in PCOS：enlarged adipocytes and low serum adiponectin，but not circulating sex steroids，are strongly associated with insulin resistance [J]. J Clin Endocrinol Metab，2011， 96（2）：E304-E311.
[18] Wild RA，Rizzo M，Clifton S，et al. Lipid levels in polycystic ovary syndrome：systematic review and meta-analysis [J]. Fertil Steril，2011，95（3）：1073-1079.
[19] 喻员员，徐键.体重指数在多囊卵巢综合症中的研究进展[J].实用妇科内分泌杂志，2018，5（16）：9-11.
[20] 张美微，马琳琳.PCOS合并妊娠期糖尿病患者母婴结局分析[J].医学研究杂志，2019，48（3）：66-70.
2020, Vol. 17 
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