Abstract：Objective To explore the clinical effect of continuous Meropenem pumping combined with Ulinastatin for injection in the treatment of severe pneumonia. Methods A total of 80 patients with severe pneumonia admitted to Wanbei Coal-Electricity Group General Hospital from January 2017 to September 2019 were divided into control group (40 cases) and observation group (40 cases) according to the random number table method. The control group was treated with Meropenem intravenous drip, while the observation group was treated with continuous intravenous pumping of Meropenem combined with intravenous drip of Ulinastatin for injection, and the treatment was continued for 7 days. The clinical efficacy, the removal of bacteria, the improvement time of clinical symptoms, the inflammatory indexes, lung function indexes before and after treatment and safety of the two groups were evaluated. Results The total effective rate and bacterial clearance rate of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The disappearance time of cough and sputum, the disappearance time of lung rales, and the time to reduce fever in the observation group were significantly shorter than those in the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, C-reactive protein, tumor necrosis factor-α, interleukin-1β, and procalcitonin in the two groups after treatment were significantly lower than those before treatment, while the observation group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). The forced end-expiratory volume in the first second, forced vital capacity, and mid-maximum respiratory flow rate of the two groups after treatment were significantly higher than those before treatment, while the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups during the treatment period (P ＞ 0.05). Conclusion Continuous infusion of Meropenem combined with Ulinastatin for injection has a better clinical effect in the treatment of severe pneumonia, which can effectively shorten the time of clinical symptoms improvement, prompt the effect of bacterial clearance, reduce inflammatory reaction and improve lung function, and has a higher safety of medication.
成维鹏 王磊 蔡振华 郭圣文. 美罗培南持续泵入联合注射用乌司他丁治疗重症肺炎的效果[J]. 中国医药导报, 2020, 17(25): 92-95,107.
CHENG Weipeng WANG Lei CAI Zhenhua GUO Shengwen. Effect of continuous Meropenem pumping combined with Ulinastatin for injection in the treatment of severe pneumonia. 中国医药导报, 2020, 17(25): 92-95,107.
2020, Vol. 17 
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