Risk factors of group B streptococcus infection during pregnancy and the influence of pregnancy outcome
HE Wei1 DENG Yao2 LU Yu1
1.Department of Obstetrics and Gynecology, Women and Children′s Hospital Affiliated to Medical College of University of Electronic Science and Technology of China Chengdu Women′s and Children′s Central Hospital, Sichuan Province, Chengdu 610071, China;
2.Department of Laboratory, Women and Children′s Hospital Affiliated to Medical College of University of Electronic Science and Technology of China Chengdu Women′s and Children′s Central Hospital, Sichuan Province, Chengdu 610071, China
Abstract：Objective To explore the risk factors of group B streptococcus (GBS) infection during pregnancy and analyze the effect of GBS infection on pregnancy outcome. Methods From January 2018 to December 2019, 15 200 pregnant women who received treatment in Department of Obstetrics, Chengdu Women′s and Children′s Central Hospital were selected as the study objects. According to the antigen test results, they were devided into GBS antigen test positive 920 cases (infection group) and GBS antigen test negative 14 280 cases (control group). Clinical data of patients was collected, the risk factors of GBS infection in pregnancy were analyzed by multiple logistic regression. Pregnancy outcome and maternal and child clinical outcome were tracked. Results The proportion of patients with age ≥ 35 years old, history of abortion, vaginitis, gestational diabetes and vaginal microecology score (Nugent score) ≥ 4 points in infection group were higher than those in control group (all P ＜ 0.05）, and the proportion of undergraduates and above, living cities and participating in perinatal health care were lower than those in control group (all P < 0.05). Multiple logistic regression analysis showed that age ≥ 35 years old, history of abortion, vaginitis, gestational diabetes and Nugent score ≥ 4 points were the high risk factors of GBS infection in pregnancy (OR = 1.865, 2.073, 15.656, 14.129, 14.089, all P < 0.05). The incidence of cesarean section, preterm delivery, low birth weight, GBS infection in newborn in infection group were higher than those in control group (P < 0.05). Conclusion The infection rate of GBS in pregnancy is high. The high risk group of GBS infection is the elderly parturient, history of abortion, vaginitis, gestational diabetes and high Nugent score, who have high risk of adverse pregnancy outcome.
何伟1 邓耀2 卢彧1. 妊娠期B族溶血性链球菌感染的危险因素分析及妊娠结局的影响[J]. 中国医药导报, 2020, 17(23): 78-81.
HE Wei1 DENG Yao2 LU Yu1. Risk factors of group B streptococcus infection during pregnancy and the influence of pregnancy outcome. 中国医药导报, 2020, 17(23): 78-81.
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2020, Vol. 17 
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