Correlation study of serum neuromodulin-1, EEG γ activity and cognitive function in first-episode schizophrenia
WANG Jindong1 ZHOU Tiantian1 CHEN Xiaoqin2 SUN Ping3 WANG Bailing1
1.Department of Geriatrics, Qingdao Mental Health Center, Shandong Province, Qingdao 266034, China;
2.Department of Substance Dependence, Qingdao Mental Health Center, Shandong Province, Qingdao 266034, China;
3.the Second Department of Geriatrics, Qingdao Mental Health Center, Shandong Province, Qingdao 266034, China
Abstract：Objective To investigate the correlation among serum neuregulin-1 (NRG-1) level, EEG γ activity and cognitive function in patients with first-episode schizophrenia. Methods A total of 80 first-episode schizophrenic patients admitted to Qingdao Mental Health Center, Shandong Province (hereinafter referred to as “our hospital”) from January 2018 to August 2019 were randomly selected as the study group, and another 50 healthy people who underwent physical examination in our hospital during the same period were selected as the control group. The serum NRG-1 level and EEG γ activity of the two groups were detected. The condition of the study group was evaluated by the positive and negative symptom scale (PANSS), and the cognitive function of the two groups was evaluated by the MATRICS recognized cognitive battery test (MCCB). The correlation among NRG-1 level, EEG γ activity and cognitive function in the study group was analyzed. Results The NRG-1 level and the positive proportion of EEG γ activity in the study group were higher than those in the control group, while the processing speed, attention alertness, working memory, verbal memory, visual memory and reasoning resolution scores in the MCCB were all lower than those in the control group, and the differences were statistically significant (all P ＜ 0.05). Compared with patients with EEG γ activity in negative, the NRG-1 level and each MCCB factor scores (processing speed, attention alertness, working memory, verbal memory, visual memory and reasoning resolution) of patients with positive EEG γ activity were all decreased, and PANSS spirit of positive symptoms, negative symptoms, general psychopathology and total score were all increased, and the differences were statistically significant (all P ＜ 0.05). The level of NRG-1 in the study group was positively correlated with the score of verbal memory and reasoning resolution (r = 0.433, 0.554; P < 0.01), but negatively correlated with the total score of PANSS (r = -0.584, P ＜ 0.01). The EEG γ activity in the study group was negatively correlated with NRG-1 level, verbal memory and reasoning resolution score (r = -0.520, -0.610, -0.541; P < 0.01), but positively correlated with the total score of PANSS (r = 0.687; P ＜ 0.01). Conclusion In patients with first-onset schizophrenia, the level of serum NRG-1 is significantly decreased, and the EEG γ activity is significantly increased. Both of them are significantly related to the patients′ condition and cognitive function, patients can be given early personalized treatment clinically.
王金东1 周田田1 陈晓芹2 孙平3 王百灵1. 首发精神分裂症血清神经调节蛋白 -1、脑电图γ活动及认知功能相关研究[J]. 中国医药导报, 2020, 17(23): 57-61.
WANG Jindong1 ZHOU Tiantian1 CHEN Xiaoqin2 SUN Ping3 WANG Bailing1. Correlation study of serum neuromodulin-1, EEG γ activity and cognitive function in first-episode schizophrenia. 中国医药导报, 2020, 17(23): 57-61.
[1] 李婷，康敏敏，黄正元，等.首发精神分裂症血清神经调节蛋白-1、脑电图γ活动及认知功能相关研究[J].中国神经精神疾病杂志，2019，45（7）：390-394.
[2] 宋双，钟镝，陈洪苹.NRG-1亚型及相关信号通路在周围神经疾病中的研究[J].脑与神经疾病杂志，2017，25（12）：790-792.
[3] Jo JY，Shin DH，Han JY. Abstract 3989：Dual targeting of ErbB2/ErbB3 for treatment of SCL3A2-NRG1-mediated lung cancer [J]. Cancer Res，2018，78（13 Supplement）：3989.
[4] 王心刚.神经电生理诊断技术规范（续）[J].现代电生理学杂志，2017，24（4）：228-251.
[5] 单广振，陈伟，郑娟.抗γ-氨基丁酸B型受体脑炎患者的临床及脑电图特征分析[J].中华诊断学电子杂志，2017， 5（3）：200-204.
[6] Xia D，Le LP，Iafrate AJ，et al. KIF13B-NRG1 Gene Fusion and KRAS Amplification in a Case of Natural Progression of Lung Cancer [J]. Int J Surg Pathol，2017，25（3）：238-240.
[7] 赵晓鑫，姚晶晶，李玉晶，等.首发未服药精神分裂症患者白质异常与面孔情绪认知障碍的关联研究[J].中华行为医学与脑科学杂志，2018，27（1）：40-46.
[8] 卢韬，欧阳梅，易咏红.神经调节蛋白1受体ErbB4在FMR1基因敲除小鼠脑组织中的表达变化及意义[J].中华神经医学杂志，2017，16（11）：1134-1138.
[9] Jiang Y，McCombs JS，Park SH. A Retrospective Cohort Study of Acute Kidney Injury Risk Associated with Antipsychotics [J]. CNS drugs，2017，31（4）：319-326.
[10] Trombetta D，Rossi G，Sparaneo A，et al. Abstract 494：Frequent NRG1 genomic rearrangements in invasive mucinous adenocarcinoma from caucasian patients [J]. Cancer Res，2017，77（13 Supplement）：494.
[11] 张慧慧，孙艳艳，李国忠，等.神经调节蛋白1与周围神经疾病的研究进展[J].神经疾病与精神卫生，2015（4）：410-412.
[12] 王亚康，朱超，罗卓荆.NRG-1参与髓鞘再生及修复的研究进展[J].神经解剖学杂志，2015，31（3）：382-386.
[13] Seeck M，Koessler L，Bast T，et al. The standardized EEG electrode array of the IFCN [J]. Clin Neurophysiol，2017， 128（10）：2070-2077.
[14] 张程程，谷晓楚，王强，等.首发精神分裂症患者认知功能和临床特征与脑源性生长因子基因Val66Met多态性的相关性[J].中华医学遗传学杂志，2017，34（4）：592-596.
[15] Kenyon LK，Farris JP，Aldrich NJ，et al. Does power mobility training impact a child′s mastery motivation and spectrum of EEG activity? An exploratory project [J]. Disabil Rehabil Assist Technol，2018，13（7）：665-673.
[16] Lai X，Zhong L，Fu HX，et al. Effects of neuregulin-1 on autonomic nervous system remodeling post-myocardial infarction in a rat model [J]. Neural Regen Res，2017，12（11）：1905-1910.
[17] Zhou Q，Wang L，Wang X，et al. Effect of neuregulin-1 on heart function and inflammatory mediators in rats with sepsis [J]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue，2018，30（2）：140-144.
[18] Naqvi HA，Huma S，Waseem H，et al. Association between a single nucleotide polymorphism in neuregulin-1 and schizophrenia in Pakistani patients [J]. J Pak Med Assoc，2018，68（5）：747-752.
[19] 王亚萍，张佩芬，袁秀霞，等.氧化应激在首发精神分裂症认知功能损害中的作用[J].中华医学杂志，2019，99（1）：9-13.
[20] 严文琼，廖湘交，陈立勇，等.舒肝解郁胶囊联合喹硫平治疗首发精神分裂症的疗效及对氧化应激水平的影响[J].中国医药科学，2019，9（16）：79-83.
[21] 徐晓津，房茂胜，缪楹，等.长期应用棕榈酸帕利哌酮治疗精神分裂症患者对其临床症状和内分泌代谢的影响[J].疑难病杂志，2019，18（4）：344-347，357.
[22] McKay JH，Tatum WO. Artifact Mimicking Ictal Epileptiform Activity in EEG [J]. J Clin Neurophysiol，2019，36（4）：275-288.
2020, Vol. 17 
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