Abstract：Diabetes mellitus and its complications have become one of the major diseases threatening human health. Apigenin is a natural flavonoid widely distributed in a variety of vegetables and fruits. Apigenin has antioxidant, anti-inflammatory and neuroprotective effects, and confirmed its effectiveness in the treatment of diabetes mellitus and its complications. This paper summarizes the mechanism of apigenin in the treatment of diabetes mellitus and its complications, including apigenin can reduce antioxidant stress, protect the mitochondrial membrane of pancreatic beta cells, increase insulin sensitivity, and activate peroxisome proliferator-activated receptor-γ (PPAR-γ) to improve hemodynamics disorder after myocardial infarction and inhibits collagen Ⅳ and fibronectin to improve renal fibrosis. These results indicate that apigenin has therapeutic and prognostic advantages in patients with diabetes mellitus and complications based on multi-target, multi-pathway and multi-layer treatment, which provides a new idea and basis for the further development of apigenin.
张纯萍. 芹菜素治疗2型糖尿病及其并发症的研究进展[J]. 中国医药导报, 2020, 17(23): 34-36.
ZHANG Chunping. Research advances of apigenin in the treatment of type 2 diabetes mellitus and its complications. 中国医药导报, 2020, 17(23): 34-36.
[1] Zhou B，Lu Y，Hajifathalian K，et al. Worldwide trends in diabetes since 1980：a pooled analysis of 751 population-based studies with 4.4 million participants [J]. Lancet，2016，387（10027）：1513-1530.
[2] Chan M. China′s burgeoning epidemic of diabetes-associated mortality [J]. JAMA，2017，317（3）：264-266.
[3] Hertog MG，Kromhout D，Aravanis C，et al. Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study [J]. Arch Internal Med，1995， 155（4）：381-386.
[4] 王慧，郑宏庭.糖尿病的抗氧化治疗与肿瘤[J].中华内分泌代谢杂志，2016，32（10）：799-802.
[5] Sampath Kumar A，Arun Maiya G，Shastry BA，et al. Correlation between basal metabolic rate，visceral fat and insulin resistance among type 2 diabetes mellitus with peripheral neuropathy [J]. Diabetes Metab Syndr，2019，13（1）：344-348.
[6] Lee E，Ryu GR，Ko SH，et al. A role of pancreatic stellate cells in islet fibrosis and β-cell dysfunction in type 2 diabetes mellitus [J]. Biochem Biophys Res Commun，2017， 485（2）：328-334.
[7] Potter KJ，Westwell-Roper CY，Klimek-Abercrombie AM，et al. Death and dysfunction of transplanted β-cells：lessons learned from type 2 diabetes? [J]. Diabetes，2014，63（1）：12-19.
[8] Yousefzadeh G，Gozashti M，Najafipour H，et al. Common autoimmune biomarkers，thyroid hormonal abnormalities，and β cells dysfunction in patients with latent autoimmune diabetes in adults with type Ⅱ diabetes mellitus [J]. Diabetes Metab Syndr，2016，10（1 Suppl 1）：S52-S55.
[9] Rahier J，Guiot Y，Goebbels RM，et al. Pancreatic β-cell mass in European subjects with type 2 diabetes [J]. Diabetes Obes Metab，2008，10 Suppl 4：32-42.
[10] Suh KS，Oh SJ，Woo JT，et al. Apigenin attenuates 2-eox-D-ribose-induced oxidative cell damage in HIT-T15 pancreatic beta-cells [J]. Biol Pharm Bull，2012，35（1）：121-126.
[11] Rukiyah T，Dross V，Hong XM，et al. Inhibition of TPA-induced cyclooxygenase-2 （COX-2） expression by apigenin through downregulation of Akt signal transduction in human keratinocytes [J]. Mol Carcinog，2005，44（2）：83-91.
[12] Jung WW. Protective effect of apigenin against oxidative stress-induced damage in osteoblastic cells [J]. Int J Mol Med，2014，33（5）：1327-1334.
[13] Montane J，Cadavez L，Novials A. Stress and the inflmmatory process：a major cause of pancreatic cell death in type 2 diabetes [J]. Diabetes Metab Syndr Obes，2014，7（2）：25-34.
[14] Trajkovski M，Hausser J，Soutschek J，et al. MicroRNAs 103 and 107 regulate insulin sensitivity [J]. Nature，2011，474（7353）：649-653.
[15] Ohno M，Shibata C，Kishikawa T，et al. The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice [J]. Sci Rep，2013，3：2553.
[16] Willeit P，Yin X，Kaudewitz D，et al. Circulating micro RNA-122 is associated with incident metabolic syndrome and type-2 diabetes [J]. Circulation，2015，132（Suppl 3）：A17961.
[17] Shibata C，Ohno M，Otsuka M，et al. The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels [J]. Virology，2014，462/463：42-48.
[18] Goto M，Yoshioka T，Battelino T，et al. TNF-alpha decreases gluconeogenesis in hepatocytes isolated from 10-day-old rats [J]. Pediatr Res，2001，49（4）：552-557.
[19] Kamagte A，Qu S，Perdomo G，et al. FoxO1 me diates insulin-dependent regulation of hepatic VLDL production in mice [J]. J Clin Invest，2008，118（6）：2347-2364.
[20] Bumke-Vogt C，Osterhoff MA，Borchert A，et al. The flavones apigenin and luteolin induce FOXO1translocation but inhibit gluconeogenic and lipogenicgene expression in human cells [J]. PLoS One，2014，9（8）：e104321.
[21] Li B，Chi RF，Qin FZ，et al. Distinct changes of myocyte autophagy during myocardial hypertrophy and heart failure：association with oxidative stress [J]. Exp Physiol，2016，101（8）：1050-1063.
[22] Balaji SP，Chand CV，Justin A，et al. Telmisartan mediates anti-inflammatory and not cognitive function through PPAR-γ agonism via SARM and MyD88 signaling [J]. Pharmacol Biochem Behav，2015，137：60-68.
[23] Jin H，Gebska MA，Blokhin IO，et al. Endothelial PPAR-γ protects against vascular thrombosis by downregulating P-selectin expression [J]. Arterioscler Thromb Vasc Biol，2015，35（4）：838-844.
[24] Buwa CC，Mahajan UB，Patil CR，et al. Apigenin attenuates β-receptor-stimulated myocardial injury via safeguarding cardiac functions and escalation of antioxidant fefence system [J]. Cardiovasc Toxicol，2016，16（3）：286-297.
[25] Lee YM，Lee G，Oh TI，et al. Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress [J]. Int J Oncol，2016，48（1）：399-408.
[26] Mahajan UB，Chandrayan G，Patil CR，et al. The protective effect of apigenin on myocardial injuryin diabetic rats mediating activation of the PPAR-gamma pathway [J]. Int J Mol Sci，2017，18（4）：756.
[27] Gutierrez-Venegas G，Gonzalez-Rosas Z. Apigenin reduce lipoteichoic acid-induced inflammatory response in rat cardiomyoblast cells [J]. Arch Pharm Res，2017，40（2）：240-249.
[28] Yang X，Yang J，Hu J，et al. Apigenin attenuates myocardial ischemia/reperfusion injury via the inactivation of p38 mitogenactivated protein kinase [J]. Mol Med Rep，2015，12（5）：6873-6878.
[29] Pourghasem M，Shafi H，Babazadeh Z. Histological changes of kidney in diabetic nephropathy [J]. Caspian J Intern Med，2015，6（3）：120-127.
[30] Malik S，Suchal K，Khan SI，et al. Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-kappaB-TNF-alpha and TGF-beta1 MAPK-fibronectin pathways [J]. Am J Physiol Renal Physiol，2017，313（2）：F414-F422.
[31] 张华，刘利祥，刘智.糖尿病合并高血压患者血清IL-6、IL-10、TNF-α水平变化及意义[J].山东医药，2015， 55（19）：79-80．
[32] Fu MS，Zhu BJ，Luo DW. Apigenin prevents TNF-α induced apoptosis of primary rat retinal ganglion cells [J]. Cell Mol Biol（Noisy-le-grand），2014，60（4）：37-42.
2020, Vol. 17 
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