Abstract：Objective To investigate the clinical efficacy and safety of Xiaoer Jiebiao Oral Liquid combined with Xiaoer Paracetamol Huangnamin Granules in the treatment of exogenous fever in children. Methods From July 2018 to April 2019, 230 children with exogenous fever who admitted to Binzhou People′s Hospital of Shandong Province were selected as objects. According to the random number table method, they were divided into control group (115 cases) and observation group (115 cases). Control group was treated with Xiaoer Paracetamol Huangnamin Granules, while observation group was treated with Xiaoer Jiebiao Oral Liquid combined with Xiaoer Paracetamol Huangnamin Granules. Both groups were given continuous treatment for three days. The clinical efficacy was evaluated after treatment. The antipyretic onset time, antipyretic time and complete antipyretic time of two groups were compared. The TCM syndrome scores and serum tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), γ interferon (IFN-γ) and C-reactive protein (CRP) levels were compared between two groups before and after treatment. The incidence of adverse reactions during the treatment was recorded and compared between two groups. Results The total clinical effective rate of observation group was higher than that of control group (P < 0.01). The antipyretic onset time, antipyretic time and complete antipyretic time of observation group were shorter than those of control group (all P < 0.01). There was no statistically significant difference in TCM syndrome scores between two groups before treatment (P > 0.05); TCM syndrome scores in two groups after treatment were lower than those before treatment, and observation group was lower than control group (all P < 0.01). Before treatment, there was no significant difference in serum TNF-α, IL-1β, IFN-γ and CRP levels between two groups (P > 0.05); after treatment, the levels of serum TNF-α, IL-1β, IFN-γ and CRP in two groups were lower than those before treatment, and observation group was lower than control group (all P < 0.05). During the treatment period, no serious adverse reactions occurred in both groups. Conclusion Xiaoer Jiebiao Oral Liquid combined with Xiaoer Paracetamol Huangnamin Granules has definite clinical efficacy in treating exogenous fever in children. It can shorten the antipyretic time, improve clinical symptoms and reduce the level of serum inflammatory factors, and has good safety.
刘福珍 李中英. 小儿解表口服液联合小儿氨酚黄那敏颗粒治疗小儿外感发热的临床研究[J]. 中国医药导报, 2020, 17(21): 117-120.
LIU Fuzhen LI Zhongying. Clinical study of Xiaoer Jiebiao Oral Liquid combined with Xiaoer Paracetamol Huangnamin Granules in the treatment of exogenous fever in children. 中国医药导报, 2020, 17(21): 117-120.
2020, Vol. 17 
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