Abstract：Objective To explore the role of MiniPDX model in guiding the treatment of advanced lung cancer patients with malignant pleural effusion. Methods A total of 30 hospitalized patients with definite diagnosis of advanced lung cancer with malignant pleural effusion were selected from Shanghai International Medical Center from June 2017 to May 2019. They were randomly divided into the MiniPDX group and the control group at 1∶1, with 15 cases in each group. Both groups had received at least first-line treatment in the past and were complicated with malignant pleural effusion after relapse or disease progression. The pleural fluid of patients in the MiniPDX group was extracted to establish a MiniPDX model, and the sensitivity of the relevant treatment drugs was detected. The results of the study were used to guide the treatment of the patients in the group. The control group received only empirical treatment. The objective remission rate (ORR), disease control rate (DCR), progression free survival (PFS), and overall survival (OS) of the two groups were compared. Results Compared with the control group, ORR and DCR in MiniPDX group were improved, OS and PFS were prolonged, and the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). Conclusion MiniPDX model has certain value in guiding the treatment of advanced lung cancer patients with malignant pleural effusion, and can improve the prognosis of patients.
贾麟 陈漪雯 姜昊声 华红伟 丁罡▲. MiniPDX模型在晚期肺癌伴恶性胸腔积液患者治疗中的指导作用[J]. 中国医药导报, 2020, 17(20): 131-134.
JIA Lin CHEN Yiwen JIANG Haosheng HUA Hongwei DING Gang▲. Guiding role of MiniPDX model in the treatment of advanced lung cancer patients with malignant pleural effusion. 中国医药导报, 2020, 17(20): 131-134.
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2020, Vol. 17 
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