Abstract：Objective To evaluate the effect of Topiramate on symptom control and electroencephalogram in children with epilepsy. Methods From February 2017 to October 2018, 100 epileptic children who admitted to Xuzhou Children′s Hospital of Jiangsu Province were selected as objects. They were divided into the control group and the study group according to the random number table method, with 50 cases in each group. The control group was treated with Oxcarbazepine, and the study group was treated with Topiramate. The clinical efficacy of the two groups was observed. Epilepsy score before and 6 months after treatment, electroencephalogram and quality of life improvement, serum neuropeptide Y (NPY), brain-derived neurotrophic factor (BD-NF) levels and adverse reactions were observed. Results The total effective rate in the study group was higher than that in the control group, and the difference was statistically significant (P < 0.05). The epilepsy scores of the two groups were compared before treatment, and the difference was not statistically significant (P > 0.05); 6 months after treatment, the epilepsy scores of the two groups were lower than those before treatment, the study group was lower than the control group, and the differences were statistically significant (all P < 0.05). Electroencephalogram improvement rate in the study group was higher than that in the control group, and the difference was statistically significant (P < 0.05). Electroencephalogram background activity of the two groups was mainly α wave activity, but there was no significant difference in the activity rates of α, θ, δ waves between the two groups (P > 0.05). There were no significant differences in NPY, BD-NF levels and QOLIE-31 scores between the two groups before treatment (P > 0.05). Six months after treatment, NPY and BD-NF levels in the two groups were lower than those before treatment, and the QOLIE-31 scores were higher than those before treatment, and the differences were statistically significant (all P < 0.05). In addition, NPY and BD-NF levels in the study group were lower than those in the control group, and QOLIE-31 scores were higher than those in the control group, with statistically significant differences (all P < 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P > 0.05). Conclusion Topiramate therapy in children with epilepsy can effectively improve the clinical treatment effectiveness and the effect of electroencephalogram, so as to effectively improve the quality of life of children.
张园 刘晓鸣 桑艳 张冬丽 赵家强. 托吡酯治疗癫痫患儿症状控制效果及脑电图的影响[J]. 中国医药导报, 2020, 17(20): 76-79,106.
ZHANG Yuan LIU Xiaoming SANG Yan ZHANG Dongli ZHAO Jiaqiang. Effect of Topiramate on symptom control and electroencephalogram in children with epilepsy. 中国医药导报, 2020, 17(20): 76-79,106.
2020, Vol. 17 
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