The relationship between the platelet to lymphocyte ratio and the stability of coronary plaque in patients with coronary heart disease
SONG Bofan1,2 Nuremanguli·Abudukeremu2 GAO Yanlin1 CHENG Wei1
1.Ward One, Department of Cardiovascular Medicine, the Second People′s Hospital of Anhui Province, Anhui Province, Hefei 230041, China;
2.Ward Two of Coronary Heart Disease, Department of Cardiovascular Medicine, the First People′s Hospital of Kashi Region, Xinjiang Uygur Autonomous Region, Kashi 844000, China
Abstract：Objective To study the relationship between platelet (PLT) to lymphocyte (LYM) ratio (PLR) and coronary plaque stability in patients with coronary heart disease (CHD). Methods Two hundred and ninety-two patients with CHD admitted to the Second People′s Hospital of Anhui Province (“our hospital” for short) from January 2016 to January 2019 were selected as CHD group. According to the characteristics of plaque, they were divided into vulnerable plaque group (155 cases) and stable plaque group (137 cases). One hundred and fifty volunteers who took physical examination in our hospital during the same period were selected as control group. Blood cell analysis, blood pressure, blood glucose, blood lipid, liver and kidney function between groups were measured. The risk factors of vulnerable plaque in CHD patients were analyzed by logistic regression, and the diagnostic value of each index was evaluated by ROC curve analysis. Results The body mass index (BMI), the percentage of hypertension and diabetes, C-reactive protein (CRP), serum creatinine (Scr), urea nitrogen (BUN), PLT and PLR in stable plaque group were higher than those in control group, and LYM was lower than that in control group, with statistically significant differences (P < 0.05). BMI, percentage of hypertension and diabetes, CRP, Scr, BUN, FIB and PLR in vulnerable plaque group were higher than those in stable plaque group and control group, triglycerides, LDL cholesterol, total cholesterol, alanine aminotransferase, leukocytes and PLT in vulnerable plaque group were higher than those in control group, LYM of vulnerable plaque group was lower than that of control group, with statistically significant differences (P < 0.05). Multivariate logistic regression analysis showed that PLR (OR = 3.320, 95%CI: 1.622-6.795, P = 0.001), CRP (OR = 2.380, 95%CI: 1.292-4.384, P = 0.005), FIB (OR = 1.862, 95%CI: 1.117-3.105, P = 0.017) were independent risk factors for CHD plaque instability. The sensitivity and specificity of three methods in the diagnosis of CHD was 0.916 and 0.891 respectively. Conclusion PLR is significantly increased in CHD patients, which is an independent risk factor for the stability of coronary plaque. Attention to PLR can guide clinical diagnosis and treatment.
宋博凡1，2 努热曼古丽·阿布都克热木2 高彦琳1 成威1. 血小板与淋巴细胞比值与冠心病患者冠脉斑块稳定性的关系[J]. 中国医药导报, 2020, 17(20): 54-57,84.
SONG Bofan1,2 Nuremanguli·Abudukeremu2 GAO Yanlin1 CHENG Wei1. The relationship between the platelet to lymphocyte ratio and the stability of coronary plaque in patients with coronary heart disease. 中国医药导报, 2020, 17(20): 54-57,84.
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