Changes of intestinal flora in patients with ulcerative colitis and its correlation with inflammatory factors and TOLL-like receptor molecules
LI Huirong1 CUI Zhao2 LIANG Bo2 LI Guodong3 HE Mingxuan4 LIU Yawei5 ZHOU Jianhua2
1.Department of Medical Laboratory, the No.2 Hospital of Baoding, Hebei Province, Baoding 071000, China;
2.Department of Medical Dermatology, the No.2 Hospital of Baoding, Hebei Province, Baoding 071000, China;
3.Department of Gastroenterology, the No.2 Hospital of Baoding, Hebei Province, Baoding 071000, China;
4.Department of Medical Oncology, Baoding First Central Hospital, Hebei Province, Baoding 071000, China;
5.Department of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Hebei University, Hebei Province, Baoding 071000, China
Abstract：Objective To investigate the changes of intestinal flora in patients with ulcerative colitis (UC) and its correlation with inflammatory factors and TOLL-like receptors (TLRs) molecules. Methods A total of 82 patients with UC admitted to the NO.2 Hospital of Baoding Hebei Province from February 2016 to August 2018 were selected as the observation group, and 70 volunteers who underwent physical examination during the same period were selected as the control group. The levels of interleukin (IL)-4, IL-6, tumor necrosis factor-α (TNF-α), intestinal flora content and the expression of TLRs molecules (TLR4 and TLR9) were detected and compared. Pearson correlation was used to analyze the correlation between TLRs expression and intestinal flora and inflammatory factors. Results The contents of Enterobacter, Bacteroides, Enterococcus and Fusobacterium in the observation group were higher than those in the control group, while the contents of Lactobacillus and Bifidobacterium in the observation group were lower than those in the control group, with statistically significant differences (all P ＜ 0.05). TLR4, TLR9, IL-6 and TNF-α in the observation group were higher than those in the control group, and IL-4 was lower than that in the control group, with statistically significant differences (all P ＜ 0.05). Pearson correlation analysis showed that TLR4 and TLR9 in UC patients were positively correlated with Enterobacter, Bacteroides, Enterococcus, Fusobacterium, IL-6 and TNF-α (r ＞ 0，P ＜ 0.05), but negatively correlated with Lactobacillus, Bifidobacterium and IL-4 (r ＜ 0，P ＜ 0.05). Conclusion In patients with UC, intestinal flora is dysregulated, which can promote the expression of TLRs molecules to increase the level of pro-inflammatory factors, reduce the level of anti-inflammatory factors, and mediate the inflammatory response of intestinal mucosa.
李会荣1 崔昭2 梁博2 李国东3 何明璇4 刘亚维5 周建华2. 溃疡性结肠炎患者肠道菌群含量变化及其与炎性因子及TOLL样受体分子的相关性[J]. 中国医药导报, 2020, 17(19): 156-159.
LI Huirong1 CUI Zhao2 LIANG Bo2 LI Guodong3 HE Mingxuan4 LIU Yawei5 ZHOU Jianhua2. Changes of intestinal flora in patients with ulcerative colitis and its correlation with inflammatory factors and TOLL-like receptor molecules. 中国医药导报, 2020, 17(19): 156-159.
2020, Vol. 17 
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