Abstract:Objective To explore the clinical effect of Huaier Granule combined with Taxol and Oxaliplatin in the treatment of advanced gastric cancer. Methods A total of 100 patients with advanced gastric cancer who were treated in Chenzhou NO.1 People′s Hospital from January 2017 to January 2019 were selected as the research object, while they were divided into observation group (50 cases) and control group (50 cases) by random number table method. The control group was treated with Taxol and Oxaliplatin, and the observation group was treated with Huaier Granules on the basis of the control group. The clinical efficacy, serum carcinoembryonic antigen (CEA), sugar chain antigen 724 (CA724), sugar chain antigen 199 (CA199), T lymphocyte subsets, quality of life and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05). After treatment, the levels of CEA, CA724, and CA199 in the two groups were significantly lower than those before treatment, while the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). The levels of CD3+, CD4+, CD4+/CD8+ in the two groups were significantly higher than those before treatment, while the observation group were higher than those in the control group; the CD8+ levels of the two groups were significantly lower than those before treatment, while the observation group was lower than the control group, and the differences were statistically significant (P < 0.05). The quality of life of the two groups were significantly higher than those before treatment, while the observation group was higher than the control group, and the differences were statistically significant (P < 0.05). The total incidence of adverse reactions between the two groups was not statistically significant (P > 0.05). Conclusion The use of Huaier Granules combined with Taxol and Oxaliplatin in patients with advanced gastric cancer has a significant effect, which can effectively improve the serum tumor marker levels and quality of life of patients.
徐明1 唐澍2 刘琦3. 槐耳颗粒联合紫杉醇和奥沙利铂治疗晚期胃癌的临床研究[J]. 中国医药导报, 2020, 17(19): 97-100.
XU Ming1 TANG Shu2 LIU Qi3. Clinical study of Huaier Granules combined with Taxol and Oxaliplatin in the treatment of advanced gastric cancer. 中国医药导报, 2020, 17(19): 97-100.