Association study on neuroimaging features and cognitive impairment of patients with cerebral microbleeds
TAN Qingjing LIU Yonghui YANG Junwei WANG Tianbao LIN Haohai
District Two, Department of Encephalopathy, the First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530023, China
Abstract：Objective To study the association between the neuroimaging features and cognitive impairment of patients with cerebral microbleeds. Methods From December 2017 to October 2019, 60 patients with cerebral microhemorrhage who admitted to the District Two, Department of Encephalopathy in the First Affiliated Hospital of Guangxi University of Chinese Medicine were selected as the observation group and 60 healthy subjects as the control group. The degree of cognitive impairment was assessed using the mini-mental state examination (MMSE) and the montreal cognitive assessment (MoCA), and the relationship between the fractional anisotropy (FA) and average diffusion coefficient (ADC) as well as the number of intracerebral microhemorrhages and cognitive impairment was observed using magnetic resonance plain scan and multimodal magnetic resonance imaging. Results The MMSE score and MoCA score of the observation group were significantly lower than those of the control group (P ＜ 0.05). FA values of frontotemporal, parietal and basal ganglia regions in the observation group were significantly lower than those in the control group (P ＜ 0.05), ADC values of frontotemporal, parietal and basal ganglia regions were higher than those in the control group (P ＜ 0.05). There was no significant difference in FA and ADC values between the two groups (P ＞ 0.05). The number of intracerebral microhemorrhage in the observation group was significantly higher than that in the control group (P ＜ 0.05). Cognitive dysfunction in patients with cerebral microvascular disease was correlated with the FA and ADC values of frontotemporal lobe and the number of intracerebral microhemorrhage (P ＜ 0.05). Conclusion The cognitive impairment in patients with cerebral microbleeds is strongly associated with the severity of white matter damage and the number of microbleeds.
谭庆晶 刘永辉 杨俊威 王天保 林浩海. 脑微出血患者神经影像学表现与认知功能障碍的相关性研究[J]. 中国医药导报, 2020, 17(19): 89-92.
TAN Qingjing LIU Yonghui YANG Junwei WANG Tianbao LIN Haohai . Association study on neuroimaging features and cognitive impairment of patients with cerebral microbleeds. 中国医药导报, 2020, 17(19): 89-92.
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2020, Vol. 17 
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