Effect of Mufangji Decoction combined with Methotrexate on oxygen free metabolism, bone metabolism and blood stasis in patients with acute rheumatoid arthritis
DING Wencong1 CHEN Taofu2 MIAO Huiyu3
1.The First Clinical School of Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510405, China;
2.Department of Traditional Chinese Medicine, Heyuan Hospital of Traditional Chinese Medicine, Guangdong Province, Heyuan 517000, China;
3.Department of Acupuncture and Massage, the Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510407, China
Abstract：Objective To explore clinical effect of Mufangji Decoction combined with Methotrexate (MTX) in the treatment of acute attack of rheumatoid arthritis (RA). Methods A total of 122 patients with acute episode RA admitted to the Third Affiliated Hospital of Guangzhou University of Chinese Medicine from January 2014 to May 2018 were selected and they were divided into the observation group (61 cases) and the control group (61 cases). The control group was orally treated with MTX + Folic Acid Tablets, and the observation group was treated with Mufangjitang on the basis of the control group. All patients were treated for 8 weeks. The clinical effects, indicators of free oxygen metabolism [total antioxidant capacity (T-AOC), superoxide dismutase (SOD), reactive oxygen species (ROS)], bone metabolism indicators [osteocalcin (BGP), type Ⅰ collagen carboxy terminal peptide β special sequence (β-CTX), propeptide of typeⅠprocollagen (PINP)], blood stasis status indicators [erythrocyte sedimentation rate (ESR), D-dimer (D-D), Fibrinogen (Fbg)] level changes, and adverse reactions of the two groups were compared before and after treatment. Results After treatment, the total effective rate in the observation group was significantly higher than that in the control group (P ＜ 0.05). After treatment, serum T-AOC, SOD, BGP, and PINP levels in the two groups were higher than those before treatment, and those of the observation group were higher than the control group (P ＜ 0.05). The concentrations of serum ROS, β-CTX, the ESR value and plasma D-D, Fbg levels in the two groups were lower than those before treatment, and those of the observation group were lower than the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Mufangji Decoction combined with Methotrexate helps patients with acute rheumatoid arthritis relieve symptoms, corrects the imbalance of oxygen free radical metabolism in body, maintains the balance of bone metabolism and improves blood stasis state with practical curative effect and high safety.
2020, Vol. 17 
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