Expression and clinical significance of Bax and nm23 protein in papillary thyroid microcarcinoma tissues
GU Guiyuan1 WANG Weige2 HUANG Shan3
1.Department of Pathology, Haian Affiliated Hospital to Nantong University, Jiangsu Province, Nantong 226600, China;
2.Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China;
3.Department of Pathology, the First Affiliated Hospital of Soochow University, Jiangsu Province, Soochow 215000, China
Abstract：Objective To study the expression and clinical significance of B lymphocyte tumor associated -2 related X protein (Bax), tumor metastasis suppressor gene 23 (nm23) protein in papillary thyroid microcarcinoma (PTMC) tissues. Methods One hundred and three paraffin specimens of PTMC patients who was given surgery treatment in Haian Affiliated Hospital to Nantong University from May 2016 to May 2017 were selected as observation group, the resection of the tumor was ≥ 5 cm far from paraffin embedded specimens of 103 cases of tumor adjacent tissues selected was as control group, another 100 patients with thyroid adenoma (TA) who was given surgery at the same time were chosen and enrolled as TA group, the expression of Bax and nm23 protein in each group was detected and compared, the relationship between the expression of Bax and nm23 protein and pathological parameters in the observation group was analyzed, and the correlation between Bax and nm23 protein was analyzed. Results The positive expression rates of Bax protein in the observation group and the TA group were significantly higher than the control group, and the differences were statistically significant (P < 0.05). The positive expression rate of nm23 protein in the observation group was significantly higher than the TA group and the control group, and the differences were statistically significant (P < 0.05). The positive expression rates of Bax and nm23 protein in the observation group with lymph node metastasis were significantly lower than without lymph node metastasis, and the differences were statistically significant (P < 0.05). According to the correlation analysis of Spearman, it was found that the expression of Bax was positively correlated with the expression of nm23 protein (r = 0.617, P < 0.05). Conclusion The expression of Bax and nm23 protein in PTMC tissues increased significantly, it is closely related to lymph node metastasis and both two indexes can be used as a monitoring target to evaluate the condition and prognosis of PTMC patients.
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2017, Vol. 14 
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